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The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion.
Nakatsu Y, Mori K, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mitsuzaki-Miyoshi K, Sakoda H, Fujishiro M, Yamaguchi S, Kushiyama A, Ono H, Ishihara H, Asano T. Nakatsu Y, et al. Among authors: asano t. J Biol Chem. 2017 Jul 14;292(28):11886-11895. doi: 10.1074/jbc.M117.780726. Epub 2017 May 31. J Biol Chem. 2017. PMID: 28566287 Free PMC article.
Development of Pin1 Inhibitors and their Potential as Therapeutic Agents.
Nakatsu Y, Matsunaga Y, Ueda K, Yamamotoya T, Inoue Y, Inoue MK, Mizuno Y, Kushiyama A, Ono H, Fujishiro M, Ito H, Okabe T, Asano T. Nakatsu Y, et al. Among authors: asano t. Curr Med Chem. 2020;27(20):3314-3329. doi: 10.2174/0929867325666181105120911. Curr Med Chem. 2020. PMID: 30394205 Review.
Pathological Role of Pin1 in the Development of DSS-Induced Colitis.
Matsunaga Y, Hasei S, Yamamotoya T, Honda H, Kushiyama A, Sakoda H, Fujishiro M, Ono H, Ito H, Okabe T, Asano T, Nakatsu Y. Matsunaga Y, et al. Among authors: asano t. Cells. 2021 May 17;10(5):1230. doi: 10.3390/cells10051230. Cells. 2021. PMID: 34067858 Free PMC article.
Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis.
Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi S, Kurihara H, Uchida T, Asano T. Nakatsu Y, et al. Among authors: asano t. J Biol Chem. 2011 Jun 10;286(23):20812-22. doi: 10.1074/jbc.M110.206904. Epub 2011 Mar 17. J Biol Chem. 2011. PMID: 21454638 Free PMC article.
Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.
Zhang J, Nakatsu Y, Shinjo T, Guo Y, Sakoda H, Yamamotoya T, Otani Y, Okubo H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Iwashita M, Nishimura F, Katagiri H, Takahashi S, Kurihara H, Uchida T, Asano T. Zhang J, et al. Among authors: asano t. J Biol Chem. 2013 Jul 12;288(28):20692-701. doi: 10.1074/jbc.M113.485730. Epub 2013 May 29. J Biol Chem. 2013. PMID: 23720771 Free PMC article.
Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines.
Kanaoka R, Kushiyama A, Seno Y, Nakatsu Y, Matsunaga Y, Fukushima T, Tsuchiya Y, Sakoda H, Fujishiro M, Yamamotoya T, Kamata H, Matsubara A, Asano T. Kanaoka R, et al. Among authors: asano t. PLoS One. 2015 Jun 3;10(6):e0127467. doi: 10.1371/journal.pone.0127467. eCollection 2015. PLoS One. 2015. PMID: 26039047 Free PMC article.
Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit.
Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T. Nakatsu Y, et al. Among authors: asano t. J Biol Chem. 2015 Oct 2;290(40):24255-66. doi: 10.1074/jbc.M115.658559. Epub 2015 Aug 14. J Biol Chem. 2015. PMID: 26276391 Free PMC article.
2,924 results