Konrat R - Search Results

1

A Step toward NRF2-DNA Interaction Inhibitors by Fragment-Based NMR Methods.

Brüschweiler S, Fuchs JE, Bader G, McConnell DB, Konrat R, Mayer M. Brüschweiler S, et al. Among authors: konrat r. ChemMedChem. 2021 Dec 6;16(23):3576-3587. doi: 10.1002/cmdc.202100458. Epub 2021 Oct 8. ChemMedChem. 2021. PMID: 34524728 Free PMC article.

2

Direct observation of the dynamic process underlying allosteric signal transmission.

Brüschweiler S, Schanda P, Kloiber K, Brutscher B, Kontaxis G, Konrat R, Tollinger M. Brüschweiler S, et al. Among authors: konrat r. J Am Chem Soc. 2009 Mar 4;131(8):3063-8. doi: 10.1021/ja809947w. J Am Chem Soc. 2009. PMID: 19203263

3

Toward rational fragment-based lead design without 3D structures.

Henen MA, Coudevylle N, Geist L, Konrat R. Henen MA, et al. Among authors: konrat r. J Med Chem. 2012 Sep 13;55(17):7909-19. doi: 10.1021/jm301016m. Epub 2012 Aug 30. J Med Chem. 2012. PMID: 22889313 Free PMC article.

4

Allosteric communication in the KIX domain proceeds through dynamic repacking of the hydrophobic core.

Brüschweiler S, Konrat R, Tollinger M. Brüschweiler S, et al. Among authors: konrat r. ACS Chem Biol. 2013 Jul 19;8(7):1600-10. doi: 10.1021/cb4002188. Epub 2013 May 20. ACS Chem Biol. 2013. PMID: 23651431 Free PMC article.

5

Direct NMR Probing of Hydration Shells of Protein Ligand Interfaces and Its Application to Drug Design.

Geist L, Mayer M, Cockcroft XL, Wolkerstorfer B, Kessler D, Engelhardt H, McConnell DB, Konrat R. Geist L, et al. Among authors: konrat r. J Med Chem. 2017 Nov 9;60(21):8708-8715. doi: 10.1021/acs.jmedchem.7b00845. Epub 2017 Oct 1. J Med Chem. 2017. PMID: 28910100

6

Selective targeting of 3 repeat Tau with brain penetrating single chain antibodies for the treatment of neurodegenerative disorders.

Spencer B, Brüschweiler S, Sealey-Cardona M, Rockenstein E, Adame A, Florio J, Mante M, Trinh I, Rissman RA, Konrat R, Masliah E. Spencer B, et al. Among authors: konrat r. Acta Neuropathol. 2018 Jul;136(1):69-87. doi: 10.1007/s00401-018-1869-0. Epub 2018 Jun 14. Acta Neuropathol. 2018. PMID: 29934874 Free PMC article.

7

PI by NMR: Probing CH-π Interactions in Protein-Ligand Complexes by NMR Spectroscopy.

Platzer G, Mayer M, Beier A, Brüschweiler S, Fuchs JE, Engelhardt H, Geist L, Bader G, Schörghuber J, Lichtenecker R, Wolkerstorfer B, Kessler D, McConnell DB, Konrat R. Platzer G, et al. Among authors: konrat r. Angew Chem Int Ed Engl. 2020 Aug 24;59(35):14861-14868. doi: 10.1002/anie.202003732. Epub 2020 Jul 15. Angew Chem Int Ed Engl. 2020. PMID: 32421895 Free PMC article.

8

Temperature as an Extra Dimension in Multidimensional Protein NMR Spectroscopy.

Shchukina A, Małecki P, Mateos B, Nowakowski M, Urbańczyk M, Kontaxis G, Kasprzak P, Conrad-Billroth C, Konrat R, Kazimierczuk K. Shchukina A, et al. Among authors: konrat r. Chemistry. 2021 Jan 21;27(5):1753-1767. doi: 10.1002/chem.202003678. Epub 2020 Dec 23. Chemistry. 2021. PMID: 32985764

9

Synthesis of a ¹³C-methylene-labeled isoleucine precursor as a useful tool for studying protein side-chain interactions and dynamics.

Höfurthner T, Toscano G, Kontaxis G, Beier A, Mayer M, Geist L, McConnell DB, Weinstabl H, Lichtenecker R, Konrat R. Höfurthner T, et al. Among authors: konrat r. J Biomol NMR. 2024 Mar;78(1):1-8. doi: 10.1007/s10858-023-00427-2. Epub 2023 Oct 11. J Biomol NMR. 2024. PMID: 37816933 Free PMC article.

10

Ligand ¹ H NMR Chemical Shifts as Accurate Reporters for Protein-Ligand Binding Interfaces in Solution.

Platzer G, Ptaszek AL, Böttcher J, Fuchs JE, Geist L, Braun D, McConnell DB, Konrat R, Sánchez-Murcia PA, Mayer M. Platzer G, et al. Among authors: konrat r. Chemphyschem. 2024 Jan 2;25(1):e202300636. doi: 10.1002/cphc.202300636. Epub 2023 Nov 13. Chemphyschem. 2024. PMID: 37955910

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