Czabotar PE - Search Results

1

Dynamic reconfiguration of pro-apoptotic BAK on membranes.

Sandow JJ, Tan IK, Huang AS, Masaldan S, Bernardini JP, Wardak AZ, Birkinshaw RW, Ninnis RL, Liu Z, Dalseno D, Lio D, Infusini G, Czabotar PE, Webb AI, Dewson G. Sandow JJ, et al. Among authors: czabotar pe. EMBO J. 2021 Oct 18;40(20):e107237. doi: 10.15252/embj.2020107237. Epub 2021 Sep 15. EMBO J. 2021. PMID: 34523147 Free PMC article.

2

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, Adams JM, Roberts AW, Huang DC. van Delft MF, et al. Among authors: czabotar pe. Cancer Cell. 2006 Nov;10(5):389-99. doi: 10.1016/j.ccr.2006.08.027. Cancer Cell. 2006. PMID: 17097561 Free PMC article.

3

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC. Willis SN, et al. Among authors: czabotar pe. Science. 2007 Feb 9;315(5813):856-9. doi: 10.1126/science.1133289. Science. 2007. PMID: 17289999

4

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices.

Dewson G, Kratina T, Czabotar P, Day CL, Adams JM, Kluck RM. Dewson G, et al. Mol Cell. 2009 Nov 25;36(4):696-703. doi: 10.1016/j.molcel.2009.11.008. Mol Cell. 2009. PMID: 19941828 Free article.

5

Molecular biology of Bax and Bak activation and action.

Westphal D, Dewson G, Czabotar PE, Kluck RM. Westphal D, et al. Among authors: czabotar pe. Biochim Biophys Acta. 2011 Apr;1813(4):521-31. doi: 10.1016/j.bbamcr.2010.12.019. Epub 2010 Dec 30. Biochim Biophys Acta. 2011. PMID: 21195116 Free article. Review.

6

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.

Czabotar PE, Lee EF, Thompson GV, Wardak AZ, Fairlie WD, Colman PM. Czabotar PE, et al. J Biol Chem. 2011 Mar 4;286(9):7123-31. doi: 10.1074/jbc.M110.161281. Epub 2011 Jan 3. J Biol Chem. 2011. PMID: 21199865 Free PMC article.

7

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity.

Okamoto T, Zobel K, Fedorova A, Quan C, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE. Okamoto T, et al. Among authors: czabotar pe. ACS Chem Biol. 2013 Feb 15;8(2):297-302. doi: 10.1021/cb3005403. Epub 2012 Dec 10. ACS Chem Biol. 2013. PMID: 23151250

8

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.

Czabotar PE, Westphal D, Dewson G, Ma S, Hockings C, Fairlie WD, Lee EF, Yao S, Robin AY, Smith BJ, Huang DC, Kluck RM, Adams JM, Colman PM. Czabotar PE, et al. Cell. 2013 Jan 31;152(3):519-31. doi: 10.1016/j.cell.2012.12.031. Cell. 2013. PMID: 23374347 Free article.

9

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS. Murphy JM, et al. Among authors: czabotar pe. Immunity. 2013 Sep 19;39(3):443-53. doi: 10.1016/j.immuni.2013.06.018. Epub 2013 Sep 5. Immunity. 2013. PMID: 24012422 Free article.

10

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS.

Yao S, Westphal D, Babon JJ, Thompson GV, Robin AY, Adams JM, Colman PM, Czabotar PE. Yao S, et al. Among authors: czabotar pe. Arch Biochem Biophys. 2014 Mar 1;545:33-43. doi: 10.1016/j.abb.2014.01.003. Epub 2014 Jan 13. Arch Biochem Biophys. 2014. PMID: 24434006

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