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Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration.
Irwin DC, Baek JH, Hassell K, Nuss R, Eigenberger P, Lisk C, Loomis Z, Maltzahn J, Stenmark KR, Nozik-Grayck E, Buehler PW. Irwin DC, et al. Among authors: buehler pw. Free Radic Biol Med. 2015 May;82:50-62. doi: 10.1016/j.freeradbiomed.2015.01.012. Epub 2015 Feb 2. Free Radic Biol Med. 2015. PMID: 25656991 Free PMC article.
Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis.
Schaer CA, Deuel JW, Schildknecht D, Mahmoudi L, Garcia-Rubio I, Owczarek C, Schauer S, Kissner R, Banerjee U, Palmer AF, Spahn DR, Irwin DC, Vallelian F, Buehler PW, Schaer DJ. Schaer CA, et al. Among authors: buehler pw. Am J Respir Crit Care Med. 2016 May 15;193(10):1111-22. doi: 10.1164/rccm.201510-2058OC. Am J Respir Crit Care Med. 2016. PMID: 26694989 Free PMC article.
Correction: Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation.
Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark KR, Buehler PW, Irwin DC. Loomis Z, et al. Among authors: buehler pw. PLoS One. 2017 Mar 6;12(3):e0173652. doi: 10.1371/journal.pone.0173652. eCollection 2017. PLoS One. 2017. PMID: 28264019 Free PMC article.
136 results