Huang TT - Search Results

1

A basal-level activity of ATR links replication fork surveillance and stress response.

Yin Y, Lee WTC, Gupta D, Xue H, Tonzi P, Borowiec JA, Huang TT, Modesti M, Rothenberg E. Yin Y, et al. Among authors: huang tt. Mol Cell. 2021 Oct 21;81(20):4243-4257.e6. doi: 10.1016/j.molcel.2021.08.009. Epub 2021 Sep 1. Mol Cell. 2021. PMID: 34473946 Free PMC article.

2

ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress.

Chen YH, Jones MJ, Yin Y, Crist SB, Colnaghi L, Sims RJ 3rd, Rothenberg E, Jallepalli PV, Huang TT. Chen YH, et al. Among authors: huang tt. Mol Cell. 2015 Apr 16;58(2):323-38. doi: 10.1016/j.molcel.2015.02.031. Epub 2015 Apr 2. Mol Cell. 2015. PMID: 25843623 Free PMC article.

3

Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery.

Tonzi P, Yin Y, Lee CWT, Rothenberg E, Huang TT. Tonzi P, et al. Among authors: huang tt. Elife. 2018 Nov 13;7:e41426. doi: 10.7554/eLife.41426. Elife. 2018. PMID: 30422114 Free PMC article.

4

Transcription shapes DNA replication initiation and termination in human cells.

Chen YH, Keegan S, Kahli M, Tonzi P, Fenyö D, Huang TT, Smith DJ. Chen YH, et al. Among authors: huang tt. Nat Struct Mol Biol. 2019 Jan;26(1):67-77. doi: 10.1038/s41594-018-0171-0. Epub 2018 Dec 31. Nat Struct Mol Biol. 2019. PMID: 30598550 Free PMC article.

5

Role of Y-family translesion DNA polymerases in replication stress: Implications for new cancer therapeutic targets.

Tonzi P, Huang TT. Tonzi P, et al. Among authors: huang tt. DNA Repair (Amst). 2019 Jun;78:20-26. doi: 10.1016/j.dnarep.2019.03.016. Epub 2019 Mar 29. DNA Repair (Amst). 2019. PMID: 30954011 Free PMC article. Review.

6

Transcription-replication conflicts as a source of common fragile site instability caused by BMI1-RNF2 deficiency.

Sanchez A, de Vivo A, Tonzi P, Kim J, Huang TT, Kee Y. Sanchez A, et al. Among authors: huang tt. PLoS Genet. 2020 Mar 6;16(3):e1008524. doi: 10.1371/journal.pgen.1008524. eCollection 2020 Mar. PLoS Genet. 2020. PMID: 32142505 Free PMC article.

7

Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε.

Sviderskiy VO, Blumenberg L, Gorodetsky E, Karakousi TR, Hirsh N, Alvarez SW, Terzi EM, Kaparos E, Whiten GC, Ssebyala S, Tonzi P, Mir H, Neel BG, Huang TT, Adams S, Ruggles KV, Possemato R. Sviderskiy VO, et al. Among authors: huang tt. Mol Cell. 2020 Nov 19;80(4):682-698.e7. doi: 10.1016/j.molcel.2020.10.016. Epub 2020 Nov 4. Mol Cell. 2020. PMID: 33152268 Free PMC article.

8

Monitoring genome-wide replication fork directionality by Okazaki fragment sequencing in mammalian cells.

Kit Leng Lui S, Keegan S, Tonzi P, Kahli M, Chen YH, Chalhoub N, Coleman KE, Fenyo D, Smith DJ, Huang TT. Kit Leng Lui S, et al. Among authors: huang tt. Nat Protoc. 2021 Feb;16(2):1193-1218. doi: 10.1038/s41596-020-00454-5. Epub 2021 Jan 13. Nat Protoc. 2021. PMID: 33442052 Free PMC article.

9

Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling.

Lee WTC, Yin Y, Morten MJ, Tonzi P, Gwo PP, Odermatt DC, Modesti M, Cantor SB, Gari K, Huang TT, Rothenberg E. Lee WTC, et al. Among authors: huang tt. Nat Commun. 2021 May 5;12(1):2525. doi: 10.1038/s41467-021-22830-9. Nat Commun. 2021. PMID: 33953191 Free PMC article.

10

Fused in sarcoma regulates DNA replication timing and kinetics.

Jia W, Kim SH, Scalf MA, Tonzi P, Millikin RJ, Guns WM, Liu L, Mastrocola AS, Smith LM, Huang TT, Tibbetts RS. Jia W, et al. Among authors: huang tt. J Biol Chem. 2021 Sep;297(3):101049. doi: 10.1016/j.jbc.2021.101049. Epub 2021 Aug 8. J Biol Chem. 2021. PMID: 34375640 Free PMC article.

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