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A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells.
McGovern JA, Bock N, Shafiee A, Martine LC, Wagner F, Baldwin JG, Landgraf M, Lahr CA, Meinert C, Williams ED, Pollock PM, Denham J, Russell PJ, Risbridger GP, Clements JA, Loessner D, Holzapfel BM, Hutmacher DW. McGovern JA, et al. Among authors: shafiee a. Commun Biol. 2021 Aug 30;4(1):1014. doi: 10.1038/s42003-021-02527-x. Commun Biol. 2021. PMID: 34462519 Free PMC article.
Priming of endothelial colony-forming cells in a mesenchymal niche improves engraftment and vasculogenic potential by initiating mesenchymal transition orchestrated by NOTCH signaling.
Shafiee A, Patel J, Wong HY, Donovan P, Hutmacher DW, Fisk NM, Khosrotehrani K. Shafiee A, et al. FASEB J. 2017 Feb;31(2):610-624. doi: 10.1096/fj.201600937. Epub 2016 Oct 24. FASEB J. 2017. PMID: 28045376
The collective results showed that primed ECFCs survive better and undergo a mesenchymal transition that is dependent on NOTCH signaling, resulting in significantly increased vasculogenic potential.-Shafiee, A., Patel, J., Wong, H. Y., Donovan, P., Hutmacher, …
The collective results showed that primed ECFCs survive better and undergo a mesenchymal transition that is dependent on NOTCH signal …
Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma.
Wagner F, Holzapfel BM, McGovern JA, Shafiee A, Baldwin JG, Martine LC, Lahr CA, Wunner FM, Friis T, Bas O, Boxberg M, Prodinger PM, Shokoohmand A, Moi D, Mazzieri R, Loessner D, Hutmacher DW. Wagner F, et al. Among authors: shafiee a. Biomaterials. 2018 Jul;171:230-246. doi: 10.1016/j.biomaterials.2018.04.030. Epub 2018 Apr 16. Biomaterials. 2018. PMID: 29705656
640 results