Shan H - Search Results

1

Reduced off-target effect of NG-BE4max by using NG-HiFi system.

Shan H, Liu Z, Jia Y, Chen S, Chen M, Song Y, Sui T, Lai L, Li Z. Shan H, et al. Mol Ther Nucleic Acids. 2021 May 19;25:168-172. doi: 10.1016/j.omtn.2021.05.012. eCollection 2021 Sep 3. Mol Ther Nucleic Acids. 2021. PMID: 34458002 Free PMC article.

2

Expanded targeting scope and enhanced base editing efficiency in rabbit using optimized xCas9(3.7).

Liu Z, Chen M, Shan H, Chen S, Xu Y, Song Y, Zhang Q, Yuan H, Ouyang H, Li Z, Lai L. Liu Z, et al. Among authors: shan h. Cell Mol Life Sci. 2019 Oct;76(20):4155-4164. doi: 10.1007/s00018-019-03110-8. Epub 2019 Apr 27. Cell Mol Life Sci. 2019. PMID: 31030226 Free PMC article.

3

Improved base editor for efficient editing in GC contexts in rabbits with an optimized AID-Cas9 fusion.

Liu Z, Shan H, Chen S, Chen M, Zhang Q, Lai L, Li Z. Liu Z, et al. Among authors: shan h. FASEB J. 2019 Aug;33(8):9210-9219. doi: 10.1096/fj.201900476RR. Epub 2019 May 9. FASEB J. 2019. PMID: 31071267

Overall, this work provides a series of improved tools that were generated using optimized AID-Cas9 fusions and associated engineered variants that can be used for efficient and versatile C-to-T base editing, especially in GC contexts.-Liu, Z., Shan, H., Chen, S., C …

Overall, this work provides a series of improved tools that were generated using optimized AID-Cas9 fusions and associated engineered varian …

4

Efficient and precise base editing in rabbits using human APOBEC3A-nCas9 fusions.

Liu Z, Chen S, Shan H, Zhang Q, Chen M, Lai L, Li Z. Liu Z, et al. Among authors: shan h. Cell Discov. 2019 Jun 11;5:31. doi: 10.1038/s41421-019-0099-5. eCollection 2019. Cell Discov. 2019. PMID: 31231541 Free PMC article. No abstract available.

5

Efficient base editing with expanded targeting scope using an engineered Spy-mac Cas9 variant.

Liu Z, Shan H, Chen S, Chen M, Song Y, Lai L, Li Z. Liu Z, et al. Among authors: shan h. Cell Discov. 2019 Dec 3;5:58. doi: 10.1038/s41421-019-0128-4. eCollection 2019. Cell Discov. 2019. PMID: 31814995 Free PMC article. No abstract available.

6

Highly efficient base editing with expanded targeting scope using SpCas9-NG in rabbits.

Liu Z, Shan H, Chen S, Chen M, Song Y, Lai L, Li Z. Liu Z, et al. Among authors: shan h. FASEB J. 2020 Jan;34(1):588-596. doi: 10.1096/fj.201901587R. Epub 2019 Nov 26. FASEB J. 2020. PMID: 31914687

7

Efficient base editing with high precision in rabbits using YFE-BE4max.

Liu Z, Chen S, Shan H, Jia Y, Chen M, Song Y, Lai L, Li Z. Liu Z, et al. Among authors: shan h. Cell Death Dis. 2020 Jan 20;11(1):36. doi: 10.1038/s41419-020-2244-3. Cell Death Dis. 2020. PMID: 31959743 Free PMC article.

8

AcrIIA5 Suppresses Base Editors and Reduces Their Off-Target Effects.

Liang M, Sui T, Liu Z, Chen M, Liu H, Shan H, Lai L, Li Z. Liang M, et al. Among authors: shan h. Cells. 2020 Jul 27;9(8):1786. doi: 10.3390/cells9081786. Cells. 2020. PMID: 32727031 Free PMC article.

9

CRISPR Start-Loss: A Novel and Practical Alternative for Gene Silencing through Base-Editing-Induced Start Codon Mutations.

Chen S, Xie W, Liu Z, Shan H, Chen M, Song Y, Yu H, Lai L, Li Z. Chen S, et al. Among authors: shan h. Mol Ther Nucleic Acids. 2020 Sep 4;21:1062-1073. doi: 10.1016/j.omtn.2020.07.037. Epub 2020 Jul 31. Mol Ther Nucleic Acids. 2020. PMID: 32854061 Free PMC article.

10

Precise base editing with CC context-specificity using engineered human APOBEC3G-nCas9 fusions.

Liu Z, Chen S, Shan H, Jia Y, Chen M, Song Y, Lai L, Li Z. Liu Z, et al. Among authors: shan h. BMC Biol. 2020 Aug 31;18(1):111. doi: 10.1186/s12915-020-00849-6. BMC Biol. 2020. PMID: 32867757 Free PMC article.

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