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Reduced off-target effect of NG-BE4max by using NG-HiFi system.
Shan H, Liu Z, Jia Y, Chen S, Chen M, Song Y, Sui T, Lai L, Li Z. Shan H, et al. Among authors: chen m, chen s. Mol Ther Nucleic Acids. 2021 May 19;25:168-172. doi: 10.1016/j.omtn.2021.05.012. eCollection 2021 Sep 3. Mol Ther Nucleic Acids. 2021. PMID: 34458002 Free PMC article.
Highly efficient RNA-guided base editing in rabbit.
Liu Z, Chen M, Chen S, Deng J, Song Y, Lai L, Li Z. Liu Z, et al. Among authors: chen m, chen s. Nat Commun. 2018 Jul 13;9(1):2717. doi: 10.1038/s41467-018-05232-2. Nat Commun. 2018. PMID: 30006570 Free PMC article.
The disrupted balance between hair follicles and sebaceous glands in Hoxc13-ablated rabbits.
Deng J, Chen M, Liu Z, Song Y, Sui T, Lai L, Li Z. Deng J, et al. Among authors: chen m. FASEB J. 2019 Jan;33(1):1226-1234. doi: 10.1096/fj.201800928RR. Epub 2018 Aug 20. FASEB J. 2019. PMID: 30125135
Moreover, the disrupted balance between HFs and SGs, especially in the Hoxc13(-/-) rabbits, can be used as an ideal animal model for dermatology ailments, such as acne and hypotrichosis, in preclinical studies.-Deng, J., Chen, M., Liu, Z., Song, Y., Sui, T., Lai, L. …
Moreover, the disrupted balance between HFs and SGs, especially in the Hoxc13(-/-) rabbits, can be used as an ideal animal model for dermato …
Improved base editor for efficient editing in GC contexts in rabbits with an optimized AID-Cas9 fusion.
Liu Z, Shan H, Chen S, Chen M, Zhang Q, Lai L, Li Z. Liu Z, et al. Among authors: chen m, chen s. FASEB J. 2019 Aug;33(8):9210-9219. doi: 10.1096/fj.201900476RR. Epub 2019 May 9. FASEB J. 2019. PMID: 31071267
Overall, this work provides a series of improved tools that were generated using optimized AID-Cas9 fusions and associated engineered variants that can be used for efficient and versatile C-to-T base editing, especially in GC contexts.-Liu, Z., Shan, H., Chen, S., Chen …
Overall, this work provides a series of improved tools that were generated using optimized AID-Cas9 fusions and associated engineered varian …
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