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Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway.
Drug Des Devel Ther. 2021 Aug 21;15:3643-3659. doi: 10.2147/DDDT.S317701. eCollection 2021.
Drug Des Devel Ther. 2021.
PMID: 34456560
Free PMC article.
Carvedilol attenuates carbon tetrachloride-induced liver fibrosis and hepatic sinusoidal capillarization in mice.
Wu Y, Li Z, Xiu AY, Meng DX, Wang SN, Zhang CQ.
Wu Y, et al. Among authors: xiu ay.
Drug Des Devel Ther. 2019 Aug 1;13:2667-2676. doi: 10.2147/DDDT.S210797. eCollection 2019.
Drug Des Devel Ther. 2019.
PMID: 31534314
Free PMC article.
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Carvedilol Inhibits Angiotensin II-Induced Proliferation and Contraction in Hepatic Stellate Cells through the RhoA/Rho-Kinase Pathway.
Wu Y, Li Z, Wang S, Xiu A, Zhang C.
Wu Y, et al.
Biomed Res Int. 2019 Nov 7;2019:7932046. doi: 10.1155/2019/7932046. eCollection 2019.
Biomed Res Int. 2019.
PMID: 31828132
Free PMC article.
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Upregulation of ATG9b by propranolol promotes autophagic cell death of hepatic stellate cells to improve liver fibrosis.
Wang S, Ding Q, Xiu A, Xia Y, Wang G, Zhang C.
Wang S, et al.
J Cell Mol Med. 2024 Jan;28(2):e18047. doi: 10.1111/jcmm.18047. Epub 2023 Nov 16.
J Cell Mol Med. 2024.
PMID: 37970991
Free PMC article.
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Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma.
Sun L, Li PB, Yao YF, Xiu AY, Peng Z, Bai YH, Gao YJ.
Sun L, et al. Among authors: xiu ay.
World J Gastroenterol. 2018 Mar 14;24(10):1120-1133. doi: 10.3748/wjg.v24.i10.1120.
World J Gastroenterol. 2018.
PMID: 29563756
Free PMC article.
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Partial splenic embolization combined with endoscopic therapies and NSBB decreases the variceal rebleeding rate in cirrhosis patients with hypersplenism: a multicenter randomized controlled trial.
Sun X, Zhang A, Zhou T, Wang M, Chen Y, Zhou T, Chen X, Xiu A, Peng Z, Cheng B, Liu X, Gao Y.
Sun X, et al.
Hepatol Int. 2021 Jun;15(3):741-752. doi: 10.1007/s12072-021-10155-0. Epub 2021 Feb 27.
Hepatol Int. 2021.
PMID: 33638769
Free PMC article.
Clinical Trial.
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The α-1 Adrenergic Receptor Antagonist Doxazosin Attenuates Liver Fibrosis by Alleviating Sinusoidal Capillarization and Liver Angiogenesis.
Xiu AY, Ding Q, Zhu CP, Zhang CQ.
Xiu AY, et al.
Adv Biol (Weinh). 2024 Mar 17:e2300513. doi: 10.1002/adbi.202300513. Online ahead of print.
Adv Biol (Weinh). 2024.
PMID: 38494421
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