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Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dysfunction, Favoring the Prophylactic Effect of Melatonin.
Sayed RKA, Fernández-Ortiz M, Diaz-Casado ME, Aranda-Martínez P, Fernández-Martínez J, Guerra-Librero A, Escames G, López LC, Alsaadawy RM, Acuña-Castroviejo D. Sayed RKA, et al. J Gerontol A Biol Sci Med Sci. 2019 Oct 4;74(11):1699-1708. doi: 10.1093/gerona/glz079. J Gerontol A Biol Sci Med Sci. 2019. PMID: 30869745
Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome.
Rahim I, Sayed RK, Fernández-Ortiz M, Aranda-Martínez P, Guerra-Librero A, Fernández-Martínez J, Rusanova I, Escames G, Djerdjouri B, Acuña-Castroviejo D. Rahim I, et al. Naunyn Schmiedebergs Arch Pharmacol. 2021 Feb;394(2):261-277. doi: 10.1007/s00210-020-01972-5. Epub 2020 Sep 16. Naunyn Schmiedebergs Arch Pharmacol. 2021. PMID: 32936353
Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging.
Fernández-Ortiz M, Sayed RKA, Fernández-Martínez J, Cionfrini A, Aranda-Martínez P, Escames G, de Haro T, Acuña-Castroviejo D. Fernández-Ortiz M, et al. Antioxidants (Basel). 2020 Nov 27;9(12):1187. doi: 10.3390/antiox9121187. Antioxidants (Basel). 2020. PMID: 33260800 Free PMC article.
The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle.
Sayed RK, Fernández-Ortiz M, Fernández-Martínez J, Aranda Martínez P, Guerra-Librero A, Rodríguez-Santana C, de Haro T, Escames G, Acuña-Castroviejo D, Rusanova I. Sayed RK, et al. Among authors: fernandez ortiz m. Antioxidants (Basel). 2021 Mar 27;10(4):524. doi: 10.3390/antiox10040524. Antioxidants (Basel). 2021. PMID: 33801675 Free PMC article.
The benefit of a supplement with the antioxidant melatonin on redox status and muscle damage in resistance-trained athletes.
Leonardo-Mendonça RC, Ocaña-Wilhelmi J, de Haro T, de Teresa-Galván C, Guerra-Hernández E, Rusanova I, Fernández-Ortiz M, Sayed RKA, Escames G, Acuña-Castroviejo D. Leonardo-Mendonça RC, et al. Appl Physiol Nutr Metab. 2017 Jul;42(7):700-707. doi: 10.1139/apnm-2016-0677. Epub 2017 Feb 13. Appl Physiol Nutr Metab. 2017. PMID: 28192673 Clinical Trial.
Melatonin, clock genes and mitochondria in sepsis.
Acuña-Castroviejo D, Rahim I, Acuña-Fernández C, Fernández-Ortiz M, Solera-Marín J, Sayed RKA, Díaz-Casado ME, Rusanova I, López LC, Escames G. Acuña-Castroviejo D, et al. Cell Mol Life Sci. 2017 Nov;74(21):3965-3987. doi: 10.1007/s00018-017-2610-1. Epub 2017 Aug 7. Cell Mol Life Sci. 2017. PMID: 28785808 Free PMC article. Review.
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