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Page 1
Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice.
Fujita M, Scheffer DDL, Turnes BL, Cronin SJF, Latrémolière A, Costigan M, Woolf CJ, Latini A, Andrews NA. Fujita M, et al. Among authors: andrews na. Arthritis Rheumatol. 2020 Jan;72(1):57-66. doi: 10.1002/art.41060. Epub 2019 Nov 28. Arthritis Rheumatol. 2020. PMID: 31350812 Free PMC article.
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Latremoliere A, Wirnsberger G, Lametschwandtner G, Busslinger M, Zicha S, Latini A, Robson SC, Waisman A, Andrews N, Costigan M, Channon KM, Weiss G, Kozlov AV, Tebbe M, Johnsson K, Woolf CJ, Penninger JM. Cronin SJF, et al. Nature. 2018 Nov;563(7732):564-568. doi: 10.1038/s41586-018-0701-2. Epub 2018 Nov 7. Nature. 2018. PMID: 30405245 Free PMC article.
Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer.
Cronin SJF, Rao S, Tejada MA, Turnes BL, Licht-Mayer S, Omura T, Brenneis C, Jacobs E, Barrett L, Latremoliere A, Andrews N, Channon KM, Latini A, Arvanites AC, Davidow LS, Costigan M, Rubin LL, Penninger JM, Woolf CJ. Cronin SJF, et al. Sci Transl Med. 2022 Aug 31;14(660):eabj1531. doi: 10.1126/scitranslmed.abj1531. Epub 2022 Aug 31. Sci Transl Med. 2022. PMID: 36044597 Free PMC article.
Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Latremoliere A, Wirnsberger G, Lametschwandtner G, Busslinger M, Zicha S, Latini A, Robson SC, Waisman A, Andrews N, Costigan M, Channon KM, Weiss G, Kozlov AV, Tebbe M, Johnsson K, Woolf CJ, Penninger JM. Cronin SJF, et al. Nature. 2019 Aug;572(7769):E18. doi: 10.1038/s41586-019-1459-x. Nature. 2019. PMID: 31363232
Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.
Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, Barrett LB, Ferreirós N, Naylor A, Penninger JM, Tegeder I, Zhong J, Blagg J, Channon KM, Johnsson K, Costigan M, Woolf CJ. Latremoliere A, et al. Neuron. 2015 Jun 17;86(6):1393-406. doi: 10.1016/j.neuron.2015.05.033. Neuron. 2015. PMID: 26087165 Free PMC article.
Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients.
Sieberg CB, Taras C, Gomaa A, Nickerson C, Wong C, Ward C, Baskozos G, Bennett DLH, Ramirez JD, Themistocleous AC, Rice ASC, Shillo PR, Tesfaye S, Edwards RR, Andrews NA, Berde C, Costigan M. Sieberg CB, et al. Among authors: andrews na. Pain Rep. 2018 May 24;3(3):e651. doi: 10.1097/PR9.0000000000000651. eCollection 2018 May. Pain Rep. 2018. PMID: 29922743 Free PMC article.
Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.
Kahle KT, Schmouth JF, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, Castonguay G, Gaudet R, Mapplebeck JC, Sotocinal SG, Duan J, Ward C, Khanna AR, Mogil JS, Dion PA, Woolf CJ, Inquimbert P, Rouleau GA. Kahle KT, et al. Sci Signal. 2016 Mar 29;9(421):ra32. doi: 10.1126/scisignal.aad0163. Sci Signal. 2016. PMID: 27025876 Free PMC article.
Automated preclinical detection of mechanical pain hypersensitivity and analgesia.
Zhang Z, Roberson DP, Kotoda M, Boivin B, Bohnslav JP, González-Cano R, Yarmolinsky DA, Turnes BL, Wimalasena NK, Neufeld SQ, Barrett LB, Quintão NLM, Fattori V, Taub DG, Wiltschko AB, Andrews NA, Harvey CD, Datta SR, Woolf CJ. Zhang Z, et al. Among authors: andrews na. Pain. 2022 Dec 1;163(12):2326-2336. doi: 10.1097/j.pain.0000000000002680. Epub 2022 May 11. Pain. 2022. PMID: 35543646 Free PMC article.
54 results