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Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation.
Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS. Cil O, et al. Among authors: lin r. Transl Res. 2017 Apr;182:14-26.e4. doi: 10.1016/j.trsl.2016.10.003. Epub 2016 Oct 15. Transl Res. 2017. PMID: 27815136 Free PMC article.
Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.
Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS. Cil O, et al. Among authors: lin r. FASEB J. 2017 Feb;31(2):751-760. doi: 10.1096/fj.201600891R. Epub 2016 Nov 8. FASEB J. 2017. PMID: 27871064 Free PMC article.
(R)-BPO-27 did not impair intestinal fluid absorption or inhibit other major intestinal transporters. ...M., Lee, S., Tradtrantip, L., Yin, J., Tse, M., Zachos, N. C., Lin, R., Donowitz, M., Verkman, A. S. Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor ( …
(R)-BPO-27 did not impair intestinal fluid absorption or inhibit other major intestinal transporters. ...M., Lee, S., Tradtrantip, L. …
Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.
Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS. Duan T, et al. Among authors: lin r. FASEB J. 2019 Oct;33(10):10924-10934. doi: 10.1096/fj.201901166R. Epub 2019 Jul 3. FASEB J. 2019. PMID: 31268738 Free PMC article.
In closed colonic loops in vivo, luminal CDCA produced a robust secretory response, which was reduced by 70% by (R)-BPO-27 or in CFTR-deficient mice. In a rat model of BAD produced by intracolonic infusion of CDCA, (R)-BPO-27 reduced the elevation in stool water con …
In closed colonic loops in vivo, luminal CDCA produced a robust secretory response, which was reduced by 70% by (R)-BPO-27 or in CFTR …
NHERF3 is necessary for Escherichia coli heat-stable enterotoxin-induced inhibition of NHE3: differences in signaling in mouse small intestine and Caco-2 cells.
Chen T, Lin R, Avula L, Sarker R, Yang J, Cha B, Tse CM, McNamara G, Seidler U, Waldman S, Snook A, Bijvelds MJC, de Jonge HR, Li X, Donowitz M. Chen T, et al. Among authors: lin r. Am J Physiol Cell Physiol. 2019 Oct 1;317(4):C737-C748. doi: 10.1152/ajpcell.00351.2018. Epub 2019 Jul 31. Am J Physiol Cell Physiol. 2019. PMID: 31365292 Free PMC article.
6,484 results