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A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex.
ACS Chem Biol. 2021 Sep 17;16(9):1721-1736. doi: 10.1021/acschembio.1c00429. Epub 2021 Aug 20.
ACS Chem Biol. 2021.
PMID: 34415726
Free PMC article.
Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing.
Barnash KD, Lamb KN, Stuckey JI, Norris JL, Cholensky SH, Kireev DB, Frye SV, James LI.
Barnash KD, et al.
ACS Chem Biol. 2016 Sep 16;11(9):2475-83. doi: 10.1021/acschembio.6b00415. Epub 2016 Jul 14.
ACS Chem Biol. 2016.
PMID: 27356154
Free PMC article.
Item in Clipboard
Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.
Barnash KD, The J, Norris-Drouin JL, Cholensky SH, Worley BM, Li F, Stuckey JI, Brown PJ, Vedadi M, Arrowsmith CH, Frye SV, James LI.
Barnash KD, et al.
ACS Comb Sci. 2017 Mar 13;19(3):161-172. doi: 10.1021/acscombsci.6b00174. Epub 2017 Feb 22.
ACS Comb Sci. 2017.
PMID: 28165227
Free PMC article.
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Target class drug discovery.
Barnash KD, James LI, Frye SV.
Barnash KD, et al.
Nat Chem Biol. 2017 Sep 19;13(10):1053-1056. doi: 10.1038/nchembio.2473.
Nat Chem Biol. 2017.
PMID: 28926557
Free PMC article.
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Design, synthesis, and protein methyltransferase activity of a unique set of constrained amine containing compounds.
Zhou H, Che X, Bao G, Wang N, Peng L, Barnash KD, Frye SV, James LI, Bai X.
Zhou H, et al. Among authors: barnash kd.
Bioorg Med Chem Lett. 2016 Sep 15;26(18):4436-4440. doi: 10.1016/j.bmcl.2016.08.004. Epub 2016 Aug 3.
Bioorg Med Chem Lett. 2016.
PMID: 27528434
Free PMC article.
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Discovery of selective activators of PRC2 mutant EED-I363M.
Suh JL, Barnash KD, Abramyan TM, Li F, The J, Engelberg IA, Vedadi M, Brown PJ, Kireev DB, Arrowsmith CH, James LI, Frye SV.
Suh JL, et al. Among authors: barnash kd.
Sci Rep. 2019 Apr 25;9(1):6524. doi: 10.1038/s41598-019-43005-z.
Sci Rep. 2019.
PMID: 31024026
Free PMC article.
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