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A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex.
Waybright JM, Clinkscales SE, Barnash KD, Budziszewski GR, Rectenwald JM, Chiarella AM, Norris-Drouin JL, Cholensky SH, Pearce KH, Herring LE, McGinty RK, Hathaway NA, James LI. Waybright JM, et al. Among authors: barnash kd. ACS Chem Biol. 2021 Sep 17;16(9):1721-1736. doi: 10.1021/acschembio.1c00429. Epub 2021 Aug 20. ACS Chem Biol. 2021. PMID: 34415726 Free PMC article.
Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.
Barnash KD, The J, Norris-Drouin JL, Cholensky SH, Worley BM, Li F, Stuckey JI, Brown PJ, Vedadi M, Arrowsmith CH, Frye SV, James LI. Barnash KD, et al. ACS Comb Sci. 2017 Mar 13;19(3):161-172. doi: 10.1021/acscombsci.6b00174. Epub 2017 Feb 22. ACS Comb Sci. 2017. PMID: 28165227 Free PMC article.
Target class drug discovery.
Barnash KD, James LI, Frye SV. Barnash KD, et al. Nat Chem Biol. 2017 Sep 19;13(10):1053-1056. doi: 10.1038/nchembio.2473. Nat Chem Biol. 2017. PMID: 28926557 Free PMC article.
Discovery of selective activators of PRC2 mutant EED-I363M.
Suh JL, Barnash KD, Abramyan TM, Li F, The J, Engelberg IA, Vedadi M, Brown PJ, Kireev DB, Arrowsmith CH, James LI, Frye SV. Suh JL, et al. Among authors: barnash kd. Sci Rep. 2019 Apr 25;9(1):6524. doi: 10.1038/s41598-019-43005-z. Sci Rep. 2019. PMID: 31024026 Free PMC article.