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Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.
Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, Lepioshkin A, Barilone N, Zanoni G, Porta A, Fondi M, Fani R, Baulard AR, Mikušová K, Alzari PM, Manganelli R, de Carvalho LP, Riccardi G, Cole ST, Pasca MR. Mori G, et al. Among authors: chiarelli lr. Chem Biol. 2015 Jul 23;22(7):917-27. doi: 10.1016/j.chembiol.2015.05.016. Epub 2015 Jun 18. Chem Biol. 2015. PMID: 26097035 Free PMC article.
Iron Acquisition Pathways as Targets for Antitubercular Drugs.
Meneghetti F, Villa S, Gelain A, Barlocco D, Chiarelli LR, Pasca MR, Costantino L. Meneghetti F, et al. Among authors: chiarelli lr. Curr Med Chem. 2016;23(35):4009-4026. doi: 10.2174/0929867323666160607223747. Curr Med Chem. 2016. PMID: 27281295 Review.
New prodrugs against tuberculosis.
Mori G, Chiarelli LR, Riccardi G, Pasca MR. Mori G, et al. Among authors: chiarelli lr. Drug Discov Today. 2017 Mar;22(3):519-525. doi: 10.1016/j.drudis.2016.09.006. Epub 2016 Sep 17. Drug Discov Today. 2017. PMID: 27649942 Review.
New and Old Hot Drug Targets in Tuberculosis.
Chiarelli LR, Mori G, Esposito M, Orena BS, Pasca MR. Chiarelli LR, et al. Curr Med Chem. 2016;23(33):3813-3846. doi: 10.2174/1389557516666160831164925. Curr Med Chem. 2016. PMID: 27666933 Review.
A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK.
Chiarelli LR, Mori G, Orena BS, Esposito M, Lane T, de Jesus Lopes Ribeiro AL, Degiacomi G, Zemanová J, Szádocka S, Huszár S, Palčeková Z, Manfredi M, Gosetti F, Lelièvre J, Ballell L, Kazakova E, Makarov V, Marengo E, Mikusova K, Cole ST, Riccardi G, Ekins S, Pasca MR. Chiarelli LR, et al. Sci Rep. 2018 Feb 16;8(1):3187. doi: 10.1038/s41598-018-21614-4. Sci Rep. 2018. PMID: 29453370 Free PMC article.
97 results