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Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells.
Wilmore S, Rogers-Broadway KR, Taylor J, Lemm E, Fell R, Stevenson FK, Forconi F, Steele AJ, Coldwell M, Packham G, Yeomans A. Wilmore S, et al. Among authors: yeomans a. Cell Mol Life Sci. 2021 Sep;78(17-18):6337-6349. doi: 10.1007/s00018-021-03910-x. Epub 2021 Aug 16. Cell Mol Life Sci. 2021. PMID: 34398253 Free PMC article.
PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells.
Yeomans A, Lemm E, Wilmore S, Cavell BE, Valle-Argos B, Krysov S, Hidalgo MS, Leonard E, Willis AE, Forconi F, Stevenson FK, Steele AJ, Coldwell MJ, Packham G. Yeomans A, et al. Oncotarget. 2016 Nov 15;7(46):74807-74819. doi: 10.18632/oncotarget.11655. Oncotarget. 2016. PMID: 27579538 Free PMC article.
B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells.
Taylor J, Wilmore S, Marriot S, Rogers-Broadway KR, Fell R, Minton AR, Branch T, Ashton-Key M, Coldwell M, Stevenson FK, Forconi F, Steele AJ, Packham G, Yeomans A. Taylor J, et al. Among authors: yeomans a. Cell Signal. 2022 Jun;94:110311. doi: 10.1016/j.cellsig.2022.110311. Epub 2022 Mar 16. Cell Signal. 2022. PMID: 35306137 Free PMC article.
Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity.
Peters TL, Tillotson J, Yeomans AM, Wilmore S, Lemm E, Jiménez-Romero C, Amador LA, Li L, Amin AD, Pongtornpipat P, Zerio CJ, Ambrose AJ, Paine-Murrieta G, Greninger P, Vega F, Benes CH, Packham G, Rodríguez AD, Chapman E, Schatz JH. Peters TL, et al. Among authors: yeomans am. Clin Cancer Res. 2018 Sep 1;24(17):4256-4270. doi: 10.1158/1078-0432.CCR-17-3645. Epub 2018 May 29. Clin Cancer Res. 2018. PMID: 29844128 Free PMC article.
Shooting the messenger (RNA) in B-cell lymphoma.
Yeomans A, Packham G. Yeomans A, et al. Blood. 2016 Feb 18;127(7):794-6. doi: 10.1182/blood-2015-12-685156. Blood. 2016. PMID: 26893394 Free article. No abstract available.
IL-4 enhances expression and function of surface IgM in CLL cells.
Aguilar-Hernandez MM, Blunt MD, Dobson R, Yeomans A, Thirdborough S, Larrayoz M, Smith LD, Linley A, Strefford JC, Davies A, Johnson PM, Savelyeva N, Cragg MS, Forconi F, Packham G, Stevenson FK, Steele AJ. Aguilar-Hernandez MM, et al. Among authors: yeomans a. Blood. 2016 Jun 16;127(24):3015-25. doi: 10.1182/blood-2015-11-682906. Epub 2016 Mar 21. Blood. 2016. PMID: 27002119 Free article.
Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications.
Arruga F, Bracciamà V, Vitale N, Vaisitti T, Gizzi K, Yeomans A, Coscia M, D'Arena G, Gaidano G, Allan JN, Furman RR, Packham G, Forconi F, Deaglio S. Arruga F, et al. Among authors: yeomans a. Leukemia. 2020 Feb;34(2):462-477. doi: 10.1038/s41375-019-0571-0. Epub 2019 Aug 29. Leukemia. 2020. PMID: 31467429 Free article.
47 results