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An end-to-end automated platform process for high-throughput engineering of next-generation multi-specific antibody therapeutics.
Furtmann N, Schneider M, Spindler N, Steinmann B, Li Z, Focken I, Meyer J, Dimova D, Kroll K, Leuschner WD, Debeaumont A, Mathieu M, Lange C, Dittrich W, Kruip J, Schmidt T, Birkenfeld J. Furtmann N, et al. Among authors: focken i. MAbs. 2021 Jan-Dec;13(1):1955433. doi: 10.1080/19420862.2021.1955433. MAbs. 2021. PMID: 34382900 Free PMC article.
Development and Validation of an Immuno-PET Tracer as a Companion Diagnostic Agent for Antibody-Drug Conjugate Therapy to Target the CA6 Epitope.
Ilovich O, Natarajan A, Hori S, Sathirachinda A, Kimura R, Srinivasan A, Gebauer M, Kruip J, Focken I, Lange C, Carrez C, Sassoon I, Blanc V, Sarkar SK, Gambhir SS. Ilovich O, et al. Among authors: focken i. Radiology. 2015 Jul;276(1):191-8. doi: 10.1148/radiol.15140058. Epub 2015 Feb 27. Radiology. 2015. PMID: 25734548 Free PMC article.
Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques.
Broeckel R, Fox JM, Haese N, Kreklywich CN, Sukulpovi-Petty S, Legasse A, Smith PP, Denton M, Corvey C, Krishnan S, Colgin LMA, Ducore RM, Lewis AD, Axthelm MK, Mandron M, Cortez P, Rothblatt J, Rao E, Focken I, Carter K, Sapparapau G, Crowe JE Jr, Diamond MS, Streblow DN. Broeckel R, et al. Among authors: focken i. PLoS Negl Trop Dis. 2017 Jun 19;11(6):e0005637. doi: 10.1371/journal.pntd.0005637. eCollection 2017 Jun. PLoS Negl Trop Dis. 2017. PMID: 28628616 Free PMC article.
Drug design for G-protein-coupled receptors by a ligand-based NMR method.
Bartoschek S, Klabunde T, Defossa E, Dietrich V, Stengelin S, Griesinger C, Carlomagno T, Focken I, Wendt KU. Bartoschek S, et al. Among authors: focken i. Angew Chem Int Ed Engl. 2010 Feb 15;49(8):1426-9. doi: 10.1002/anie.200905102. Angew Chem Int Ed Engl. 2010. PMID: 20084646 No abstract available.