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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
Gozgit JM, Vasbinder MM, Abo RP, Kunii K, Kuplast-Barr KG, Gui B, Lu AZ, Molina JR, Minissale E, Swinger KK, Wigle TJ, Blackwell DJ, Majer CR, Ren Y, Niepel M, Varsamis ZA, Nayak SP, Bamberg E, Mo JR, Church WD, Mady ASA, Song J, Utley L, Rao PE, Mitchison TJ, Kuntz KW, Richon VM, Keilhack H. Gozgit JM, et al. Among authors: lu az. Cancer Cell. 2021 Sep 13;39(9):1214-1226.e10. doi: 10.1016/j.ccell.2021.06.018. Epub 2021 Jul 22. Cancer Cell. 2021. PMID: 34375612 Free article.
Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.
Wigle TJ, Ren Y, Molina JR, Blackwell DJ, Schenkel LB, Swinger KK, Kuplast-Barr K, Majer CR, Church WD, Lu AZ, Mo J, Abo R, Cheung A, Dorsey BW, Niepel M, Perl NR, Vasbinder MM, Keilhack H, Kuntz KW. Wigle TJ, et al. Among authors: lu az. Chembiochem. 2021 Jun 15;22(12):2107-2110. doi: 10.1002/cbic.202100047. Epub 2021 May 4. Chembiochem. 2021. PMID: 33838082
In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement.
Wigle TJ, Blackwell DJ, Schenkel LB, Ren Y, Church WD, Desai HJ, Swinger KK, Santospago AG, Majer CR, Lu AZ, Niepel M, Perl NR, Vasbinder MM, Keilhack H, Kuntz KW. Wigle TJ, et al. Among authors: lu az. Cell Chem Biol. 2020 Jul 16;27(7):877-887.e14. doi: 10.1016/j.chembiol.2020.06.009. Cell Chem Biol. 2020. PMID: 32679093 Free article.
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.
Schenkel LB, Molina JR, Swinger KK, Abo R, Blackwell DJ, Lu AZ, Cheung AE, Church WD, Kunii K, Kuplast-Barr KG, Majer CR, Minissale E, Mo JR, Niepel M, Reik C, Ren Y, Vasbinder MM, Wigle TJ, Richon VM, Keilhack H, Kuntz KW. Schenkel LB, et al. Among authors: lu az. Cell Chem Biol. 2021 Aug 19;28(8):1158-1168.e13. doi: 10.1016/j.chembiol.2021.02.010. Epub 2021 Mar 10. Cell Chem Biol. 2021. PMID: 33705687 Free article.
Ninety Percent of Patients Are Satisfied With Their Decision to Undergo Spine Surgery for Degenerative Conditions.
Maayan O, Shahi P, Merrill RK, Pajak A, Lu AZ, Oquendo Y, Subramanian T, Araghi K, Tuma OC, Korsun MK, Asada T, Singh N, Singh S, Sheha ED, Dowdell JE, Qureshi SA, Iyer S. Maayan O, et al. Among authors: lu az. Spine (Phila Pa 1976). 2024 Apr 15;49(8):561-568. doi: 10.1097/BRS.0000000000004714. Epub 2023 May 9. Spine (Phila Pa 1976). 2024. PMID: 38533908
Predictors for Failure to Respond to Erector Spinae Plane Block Following Minimally Invasive Transforaminal Lumbar Interbody Fusion.
Mai E, Zhang J, Lu AZ, Bovonratwet P, Kim E, Simon CZ, Kwas C, Allen M, Asada T, Singh N, Tuma O, Araghi K, Korsun M, Kim YE, Heuer A, Vaishnav A, Dowdell J, Wetmore DS, Qureshi SA, Iyer S. Mai E, et al. Among authors: lu az. Spine (Phila Pa 1976). 2024 Mar 5. doi: 10.1097/BRS.0000000000004978. Online ahead of print. Spine (Phila Pa 1976). 2024. PMID: 38441111
Limited Improvement with Minimally Invasive Lumbar Decompression Alone for Degenerative Scoliosis with Cobb Angle over 20 Degrees: The Impact of Decompression Location.
Asada T, Simon CZ, Singh N, Tuma O, Subramanian T, Araghi K, Lu AZ, Mai E, Kim YE, Allen MRJ, Korsun M, Zhang J, Kwas C, Singh S, Dowdell J, Sheha ED, Qureshi SA, Iyer S. Asada T, et al. Among authors: lu az. Spine (Phila Pa 1976). 2024 Feb 20. doi: 10.1097/BRS.0000000000004968. Online ahead of print. Spine (Phila Pa 1976). 2024. PMID: 38375684
The Impact of Posterior Intervertebral Osteophytes on Patient-Reported Outcome Measures After L5-S1 Anterior Lumbar Interbody Fusion and Transforaminal Lumbar Interbody Fusion.
Zhao E, Hirase T, Kim AG, Du JY, Amen TB, Araghi K, Subramanian T, Kamil R, Shahi P, Fourman MS, Asada T, Simon CZ, Singh N, Korsun M, Tuma OC, Zhang J, Lu AZ, Mai E, Kim AYE, Allen MRJ, Kwas C, Dowdell JE, Sheha ED, Qureshi SA, Iyer S. Zhao E, et al. Among authors: lu az. Spine (Phila Pa 1976). 2024 May 1;49(9):652-660. doi: 10.1097/BRS.0000000000004904. Epub 2024 Jan 8. Spine (Phila Pa 1976). 2024. PMID: 38193931
26 results