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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
Cancer Cell. 2021 Sep 13;39(9):1214-1226.e10. doi: 10.1016/j.ccell.2021.06.018. Epub 2021 Jul 22.
Cancer Cell. 2021.
PMID: 34375612
Free article.
Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.
Wigle TJ, Ren Y, Molina JR, Blackwell DJ, Schenkel LB, Swinger KK, Kuplast-Barr K, Majer CR, Church WD, Lu AZ, Mo J, Abo R, Cheung A, Dorsey BW, Niepel M, Perl NR, Vasbinder MM, Keilhack H, Kuntz KW.
Wigle TJ, et al. Among authors: church wd.
Chembiochem. 2021 Jun 15;22(12):2107-2110. doi: 10.1002/cbic.202100047. Epub 2021 May 4.
Chembiochem. 2021.
PMID: 33838082
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Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes.
Wigle TJ, Church WD, Majer CR, Swinger KK, Aybar D, Schenkel LB, Vasbinder MM, Brendes A, Beck C, Prahm M, Wegener D, Chang P, Kuntz KW.
Wigle TJ, et al. Among authors: church wd.
SLAS Discov. 2020 Mar;25(3):241-252. doi: 10.1177/2472555219883623. Epub 2019 Dec 19.
SLAS Discov. 2020.
PMID: 31855104
Free PMC article.
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In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement.
Wigle TJ, Blackwell DJ, Schenkel LB, Ren Y, Church WD, Desai HJ, Swinger KK, Santospago AG, Majer CR, Lu AZ, Niepel M, Perl NR, Vasbinder MM, Keilhack H, Kuntz KW.
Wigle TJ, et al. Among authors: church wd.
Cell Chem Biol. 2020 Jul 16;27(7):877-887.e14. doi: 10.1016/j.chembiol.2020.06.009.
Cell Chem Biol. 2020.
PMID: 32679093
Free article.
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A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.
Schenkel LB, Molina JR, Swinger KK, Abo R, Blackwell DJ, Lu AZ, Cheung AE, Church WD, Kunii K, Kuplast-Barr KG, Majer CR, Minissale E, Mo JR, Niepel M, Reik C, Ren Y, Vasbinder MM, Wigle TJ, Richon VM, Keilhack H, Kuntz KW.
Schenkel LB, et al. Among authors: church wd.
Cell Chem Biol. 2021 Aug 19;28(8):1158-1168.e13. doi: 10.1016/j.chembiol.2021.02.010. Epub 2021 Mar 10.
Cell Chem Biol. 2021.
PMID: 33705687
Free article.
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