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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
Gozgit JM, Vasbinder MM, Abo RP, Kunii K, Kuplast-Barr KG, Gui B, Lu AZ, Molina JR, Minissale E, Swinger KK, Wigle TJ, Blackwell DJ, Majer CR, Ren Y, Niepel M, Varsamis ZA, Nayak SP, Bamberg E, Mo JR, Church WD, Mady ASA, Song J, Utley L, Rao PE, Mitchison TJ, Kuntz KW, Richon VM, Keilhack H. Gozgit JM, et al. Among authors: blackwell dj. Cancer Cell. 2021 Sep 13;39(9):1214-1226.e10. doi: 10.1016/j.ccell.2021.06.018. Epub 2021 Jul 22. Cancer Cell. 2021. PMID: 34375612 Free article.
Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.
Wigle TJ, Ren Y, Molina JR, Blackwell DJ, Schenkel LB, Swinger KK, Kuplast-Barr K, Majer CR, Church WD, Lu AZ, Mo J, Abo R, Cheung A, Dorsey BW, Niepel M, Perl NR, Vasbinder MM, Keilhack H, Kuntz KW. Wigle TJ, et al. Among authors: blackwell dj. Chembiochem. 2021 Jun 15;22(12):2107-2110. doi: 10.1002/cbic.202100047. Epub 2021 May 4. Chembiochem. 2021. PMID: 33838082
In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement.
Wigle TJ, Blackwell DJ, Schenkel LB, Ren Y, Church WD, Desai HJ, Swinger KK, Santospago AG, Majer CR, Lu AZ, Niepel M, Perl NR, Vasbinder MM, Keilhack H, Kuntz KW. Wigle TJ, et al. Among authors: blackwell dj. Cell Chem Biol. 2020 Jul 16;27(7):877-887.e14. doi: 10.1016/j.chembiol.2020.06.009. Cell Chem Biol. 2020. PMID: 32679093 Free article.
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.
Schenkel LB, Molina JR, Swinger KK, Abo R, Blackwell DJ, Lu AZ, Cheung AE, Church WD, Kunii K, Kuplast-Barr KG, Majer CR, Minissale E, Mo JR, Niepel M, Reik C, Ren Y, Vasbinder MM, Wigle TJ, Richon VM, Keilhack H, Kuntz KW. Schenkel LB, et al. Among authors: blackwell dj. Cell Chem Biol. 2021 Aug 19;28(8):1158-1168.e13. doi: 10.1016/j.chembiol.2021.02.010. Epub 2021 Mar 10. Cell Chem Biol. 2021. PMID: 33705687 Free article.
LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation.
Murphy MB, Yang Z, Subati T, Farber-Eger E, Kim K, Blackwell DJ, Fleming MR, Stark JM, Van Amburg JC, Woodall KK, Van Beusecum JP, Agrawal V, Smart CD, Pitzer A, Atkinson JB, Fogo AB, Bastarache JA, Kirabo A, Wells QS, Madhur MS, Barnett JV, Murray KT. Murphy MB, et al. Among authors: blackwell dj. Cardiovasc Res. 2024 Feb 20:cvae036. doi: 10.1093/cvr/cvae036. Online ahead of print. Cardiovasc Res. 2024. PMID: 38377486
RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET.
Šeflová J, Schwarz JA, Smith AN, Svensson B, Blackwell DJ, Phillips TA, Nikolaienko R, Bovo E, Rebbeck RT, Zima AV, Thomas DD, Van Petegem F, Knollmann BC, Johnston JN, Robia SL, Cornea RL. Šeflová J, et al. Among authors: blackwell dj. ACS Chem Biol. 2023 Oct 20;18(10):2290-2299. doi: 10.1021/acschembio.3c00376. Epub 2023 Sep 28. ACS Chem Biol. 2023. PMID: 37769131
Eicosanoid-Regulated Myeloid ENaC and Isolevuglandin Formation in Human Salt-Sensitive Hypertension.
Ertuglu LA, Pitzer Mutchler A, Jamison S, Laffer CL, Elijovich F, Saleem M, Blackwell DJ, Kryshtal DO, Egly CL, Sahinoz M, Sheng Q, Wanjalla CN, Pakala S, Yu J, Gutierrez OM, Kleyman TR, Knollmann BC, Ikizler TA, Kirabo A. Ertuglu LA, et al. Among authors: blackwell dj. Hypertension. 2024 Mar;81(3):516-529. doi: 10.1161/HYPERTENSIONAHA.123.21285. Epub 2023 Sep 7. Hypertension. 2024. PMID: 37675576 Free article.
34 results