Donnelly S - Search Results

1

The parasite-derived peptide FhHDM-1 activates the PI3K/Akt pathway to prevent cytokine-induced apoptosis of β-cells.

Camaya I, Mok TY, Lund M, To J, Braidy N, Robinson MW, Santos J, O'Brien B, Donnelly S. Camaya I, et al. Among authors: donnelly s. J Mol Med (Berl). 2021 Nov;99(11):1605-1621. doi: 10.1007/s00109-021-02122-x. Epub 2021 Aug 10. J Mol Med (Berl). 2021. PMID: 34374810

2

Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica.

Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. Stack CM, et al. Among authors: donnelly sm. J Biol Chem. 2008 Apr 11;283(15):9896-908. doi: 10.1074/jbc.M708521200. Epub 2007 Dec 26. J Biol Chem. 2008. PMID: 18160404 Free PMC article.

3

Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors.

Robinson MW, Tort JF, Lowther J, Donnelly SM, Wong E, Xu W, Stack CM, Padula M, Herbert B, Dalton JP. Robinson MW, et al. Mol Cell Proteomics. 2008 Jun;7(6):1111-23. doi: 10.1074/mcp.M700560-MCP200. Epub 2008 Feb 21. Mol Cell Proteomics. 2008. PMID: 18296439 Free article.

4

Helminth pathogen cathepsin proteases: it's a family affair.

Robinson MW, Dalton JP, Donnelly S. Robinson MW, et al. Among authors: donnelly s. Trends Biochem Sci. 2008 Dec;33(12):601-8. doi: 10.1016/j.tibs.2008.09.001. Epub 2008 Oct 8. Trends Biochem Sci. 2008. PMID: 18848453 Review.

5

The enigmatic asparaginyl endopeptidase of helminth parasites.

Dalton JP, Brindley PJ, Donnelly S, Robinson MW. Dalton JP, et al. Among authors: donnelly s. Trends Parasitol. 2009 Feb;25(2):59-61. doi: 10.1016/j.pt.2008.11.002. Epub 2008 Dec 26. Trends Parasitol. 2009. PMID: 19101207 No abstract available.

6

The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease.

Lowther J, Robinson MW, Donnelly SM, Xu W, Stack CM, Matthews JM, Dalton JP. Lowther J, et al. PLoS Negl Trop Dis. 2009;3(1):e369. doi: 10.1371/journal.pntd.0000369. Epub 2009 Jan 27. PLoS Negl Trop Dis. 2009. PMID: 19172172 Free PMC article.

7

The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors.

Maric S, Donnelly SM, Robinson MW, Skinner-Adams T, Trenholme KR, Gardiner DL, Dalton JP, Stack CM, Lowther J. Maric S, et al. Among authors: donnelly sm. Biochemistry. 2009 Jun 16;48(23):5435-9. doi: 10.1021/bi9003638. Biochemistry. 2009. PMID: 19408962

8

An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host.

Robinson MW, Menon R, Donnelly SM, Dalton JP, Ranganathan S. Robinson MW, et al. Among authors: donnelly sm. Mol Cell Proteomics. 2009 Aug;8(8):1891-907. doi: 10.1074/mcp.M900045-MCP200. Epub 2009 May 14. Mol Cell Proteomics. 2009. PMID: 19443417 Free PMC article.

9

Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3.

Donnelly S, O'Neill SM, Stack CM, Robinson MW, Turnbull L, Whitchurch C, Dalton JP. Donnelly S, et al. J Biol Chem. 2010 Jan 29;285(5):3383-92. doi: 10.1074/jbc.M109.060368. Epub 2009 Nov 18. J Biol Chem. 2010. PMID: 19923225 Free PMC article.

10

Aminopeptidases of malaria parasites: new targets for chemotherapy.

Trenholme KR, Brown CL, Skinner-Adams TS, Stack C, Lowther J, To J, Robinson MW, Donnelly SM, Dalton JP, Gardiner DL. Trenholme KR, et al. Among authors: donnelly sm. Infect Disord Drug Targets. 2010 Jun;10(3):217-25. doi: 10.2174/187152610791163363. Infect Disord Drug Targets. 2010. PMID: 20334618 Review.

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