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CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors.
Crittenden JR, Zhai S, Sauvage M, Kitsukawa T, Burguière E, Thomsen M, Zhang H, Costa C, Martella G, Ghiglieri V, Picconi B, Pescatore KA, Unterwald EM, Jackson WS, Housman DE, Caine SB, Sulzer D, Calabresi P, Smith AC, Surmeier DJ, Graybiel AM. Crittenden JR, et al. Among authors: graybiel am. Neurobiol Dis. 2021 Oct;158:105473. doi: 10.1016/j.nbd.2021.105473. Epub 2021 Aug 8. Neurobiol Dis. 2021. PMID: 34371144 Free PMC article.
A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.
Kawasaki H, Springett GM, Toki S, Canales JJ, Harlan P, Blumenstiel JP, Chen EJ, Bany IA, Mochizuki N, Ashbacher A, Matsuda M, Housman DE, Graybiel AM. Kawasaki H, et al. Among authors: graybiel am. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13278-83. doi: 10.1073/pnas.95.22.13278. Proc Natl Acad Sci U S A. 1998. PMID: 9789079 Free PMC article.
A family of cAMP-binding proteins that directly activate Rap1.
Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM. Kawasaki H, et al. Among authors: graybiel am. Science. 1998 Dec 18;282(5397):2275-9. doi: 10.1126/science.282.5397.2275. Science. 1998. PMID: 9856955
A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets.
Pasvolsky R, Feigelson SW, Kilic SS, Simon AJ, Tal-Lapidot G, Grabovsky V, Crittenden JR, Amariglio N, Safran M, Graybiel AM, Rechavi G, Ben-Dor S, Etzioni A, Alon R. Pasvolsky R, et al. Among authors: graybiel am. J Exp Med. 2007 Jul 9;204(7):1571-82. doi: 10.1084/jem.20070058. Epub 2007 Jun 18. J Exp Med. 2007. PMID: 17576779 Free PMC article.
Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy.
Crittenden JR, Cantuti-Castelvetri I, Saka E, Keller-McGandy CE, Hernandez LF, Kett LR, Young AB, Standaert DG, Graybiel AM. Crittenden JR, et al. Among authors: graybiel am. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2892-6. doi: 10.1073/pnas.0812822106. Epub 2009 Jan 26. Proc Natl Acad Sci U S A. 2009. PMID: 19171906 Free PMC article.
324 results