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A functional BH3 domain in an aquaporin from Leishmania infantum.
Genes CM, de Lucio H, González VM, Sánchez-Murcia PA, Rico E, Gago F, Fasel N, Jiménez-Ruiz A. Genes CM, et al. Among authors: de lucio h. Cell Death Discov. 2016 Jul 4;2:16043. doi: 10.1038/cddiscovery.2016.43. eCollection 2016. Cell Death Discov. 2016. PMID: 27551533 Free PMC article.
First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity.
Ruiz-Santaquiteria M, Sánchez-Murcia PA, Toro MA, de Lucio H, Gutiérrez KJ, de Castro S, Carneiro FAC, Gago F, Jiménez-Ruiz A, Camarasa MJ, Velázquez S. Ruiz-Santaquiteria M, et al. Among authors: de lucio h, de castro s. Eur J Med Chem. 2017 Jul 28;135:49-59. doi: 10.1016/j.ejmech.2017.04.020. Epub 2017 Apr 13. Eur J Med Chem. 2017. PMID: 28431354 Free article.
Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides.
de Lucio H, Gamo AM, Ruiz-Santaquiteria M, de Castro S, Sánchez-Murcia PA, Toro MA, Gutiérrez KJ, Gago F, Jiménez-Ruiz A, Camarasa MJ, Velázquez S. de Lucio H, et al. Among authors: de castro s. Eur J Med Chem. 2017 Nov 10;140:615-623. doi: 10.1016/j.ejmech.2017.09.032. Epub 2017 Sep 21. Eur J Med Chem. 2017. PMID: 29017116 Free article.
Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability.
Ruiz-Santaquiteria M, de Castro S, Toro MA, de Lucio H, Gutiérrez KJ, Sánchez-Murcia PA, Jiménez MÁ, Gago F, Jiménez-Ruiz A, Camarasa MJ, Velázquez S. Ruiz-Santaquiteria M, et al. Among authors: de lucio h. Eur J Med Chem. 2018 Apr 10;149:238-247. doi: 10.1016/j.ejmech.2018.02.071. Epub 2018 Feb 24. Eur J Med Chem. 2018. PMID: 29501944 Free article.
Identification of NEK3 and MOK as novel targets for lithium.
Bravo A, de Lucio H, Sánchez-Murcia PA, Jiménez-Ruiz A, Petrone PM, Gago F, Cortés Cabrera A. Bravo A, et al. Among authors: de lucio h. Chem Biol Drug Des. 2019 May;93(5):965-969. doi: 10.1111/cbdd.13487. Epub 2019 Feb 12. Chem Biol Drug Des. 2019. PMID: 30667602
Synthesis and Leishmanicidal Activity of Novel Urea, Thiourea, and Selenourea Derivatives of Diselenides.
Díaz M, de Lucio H, Moreno E, Espuelas S, Aydillo C, Jiménez-Ruiz A, Toro MÁ, Gutiérrez KJ, Martínez-Merino V, Cornejo A, Palop JA, Sanmartín C, Plano D. Díaz M, et al. Among authors: de lucio h. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e02200-18. doi: 10.1128/AAC.02200-18. Print 2019 May. Antimicrob Agents Chemother. 2019. PMID: 30782984 Free PMC article.
Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase.
Revuelto A, Ruiz-Santaquiteria M, de Lucio H, Gamo A, Carriles AA, Gutiérrez KJ, Sánchez-Murcia PA, Hermoso JA, Gago F, Camarasa MJ, Jiménez-Ruiz A, Velázquez S. Revuelto A, et al. Among authors: de lucio h. ACS Infect Dis. 2019 Jun 14;5(6):873-891. doi: 10.1021/acsinfecdis.8b00355. Epub 2019 Apr 23. ACS Infect Dis. 2019. PMID: 30983322
14 results