Lafferty RA - Search Results

1

Physicochemical, Nutritional and In Vitro Antidiabetic Characterisation of Blue Whiting (Micromesistiuspoutassou) Protein Hydrolysates.

Harnedy-Rothwell PA, Khatib N, Sharkey S, Lafferty RA, Gite S, Whooley J, O'Harte FP, FitzGerald RJ. Harnedy-Rothwell PA, et al. Among authors: lafferty ra. Mar Drugs. 2021 Jul 2;19(7):383. doi: 10.3390/md19070383. Mar Drugs. 2021. PMID: 34356808 Free PMC article.

2

Development and characterisation of a peptidergic N-and C-terminally stabilised mammalian NPY1R agonist which protects against diabetes induction.

Lafferty RA, Tanday N, Flatt PR, Irwin N. Lafferty RA, et al. Biochim Biophys Acta Gen Subj. 2020 May;1864(5):129543. doi: 10.1016/j.bbagen.2020.129543. Epub 2020 Jan 30. Biochim Biophys Acta Gen Subj. 2020. PMID: 32007578

3

Macroalgal protein hydrolysates from Palmaria palmata influence the 'incretin effect' in vitro via DPP-4 inhibition and upregulation of insulin, GLP-1 and GIP secretion.

McLaughlin CM, Harnedy-Rothwell PA, Lafferty RA, Sharkey S, Parthsarathy V, Allsopp PJ, McSorley EM, FitzGerald RJ, O'Harte FPM. McLaughlin CM, et al. Among authors: lafferty ra. Eur J Nutr. 2021 Dec;60(8):4439-4452. doi: 10.1007/s00394-021-02583-3. Epub 2021 Jun 3. Eur J Nutr. 2021. PMID: 34081167 Free PMC article.

4

Proglucagon-Derived Peptides as Therapeutics.

Lafferty RA, O'Harte FPM, Irwin N, Gault VA, Flatt PR. Lafferty RA, et al. Front Endocrinol (Lausanne). 2021 May 18;12:689678. doi: 10.3389/fendo.2021.689678. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34093449 Free PMC article. Review.

5

Metabolic effects of combined glucagon receptor antagonism and glucagon-like peptide-1 receptor agonism in high fat fed mice.

Franklin ZJ, Lafferty RA, Flatt PR, McShane LM, O'Harte FPM, Irwin N. Franklin ZJ, et al. Among authors: lafferty ra. Biochimie. 2022 Aug;199:60-67. doi: 10.1016/j.biochi.2022.04.005. Epub 2022 Apr 16. Biochimie. 2022. PMID: 35439540 Free article.

6

Sustained glucagon receptor antagonism in insulin-deficient high-fat-fed mice.

Lafferty RA, McShane LM, Franklin ZJ, Flatt PR, O'Harte FPM, Irwin N. Lafferty RA, et al. J Endocrinol. 2022 Sep 14;255(2):91-101. doi: 10.1530/JOE-22-0106. Print 2022 Nov 1. J Endocrinol. 2022. PMID: 36005280 Free PMC article.

7

The glucagon receptor antagonist desHis¹Pro⁴Glu⁹-glucagon(Lys¹²PAL) alters alpha-cell turnover and lineage in mice, but does not cause alpha-cell hyperplasia.

Lafferty R, Tanday N, Dubey V, Coulter-Parkhill A, Vishal K, Moffett C, O'Harte F, Flatt PR, Irwin N. Lafferty R, et al. Mol Cell Endocrinol. 2023 Jun 15;570:111932. doi: 10.1016/j.mce.2023.111932. Epub 2023 Apr 18. Mol Cell Endocrinol. 2023. PMID: 37080378 Free article.

8

Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes.

Tanday N, English A, Lafferty RA, Flatt PR, Irwin N. Tanday N, et al. Among authors: lafferty ra. Front Endocrinol (Lausanne). 2021 May 14;12:674704. doi: 10.3389/fendo.2021.674704. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34054734 Free PMC article.

9

C-terminal degradation of PYY peptides in plasma abolishes effects on satiety and beta-cell function.

Lafferty RA, Flatt PR, Irwin N. Lafferty RA, et al. Biochem Pharmacol. 2018 Dec;158:95-102. doi: 10.1016/j.bcp.2018.10.004. Epub 2018 Oct 5. Biochem Pharmacol. 2018. PMID: 30292757

10

Peptide YY (1-36) peptides from phylogenetically ancient fish targeting mammalian neuropeptide Y1 receptors demonstrate potent effects on pancreatic β-cell function, growth and survival.

Lafferty RA, Tanday N, McCloskey A, Bompada P, De Marinis Y, Flatt PR, Irwin N. Lafferty RA, et al. Diabetes Obes Metab. 2020 Mar;22(3):404-416. doi: 10.1111/dom.13908. Epub 2019 Dec 9. Diabetes Obes Metab. 2020. PMID: 31692207

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