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Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle.
Bhardwaj G, Penniman CM, Jena J, Suarez Beltran PA, Foster C, Poro K, Junck TL, Hinton AO Jr, Souvenir R, Fuqua JD, Morales PE, Bravo-Sagua R, Sivitz WI, Lira VA, Abel ED, O'Neill BT. Bhardwaj G, et al. Among authors: abel ed. J Clin Invest. 2021 Sep 15;131(18):e146415. doi: 10.1172/JCI146415. J Clin Invest. 2021. PMID: 34343133 Free PMC article.
Akt1 in the cardiovascular system: friend or foe?
O'Neill BT, Abel ED. O'Neill BT, et al. Among authors: abel ed. J Clin Invest. 2005 Aug;115(8):2059-64. doi: 10.1172/JCI25900. J Clin Invest. 2005. PMID: 16075047 Free PMC article.
Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.
Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED. Boudina S, et al. Among authors: abel ed. Circulation. 2009 Mar 10;119(9):1272-83. doi: 10.1161/CIRCULATIONAHA.108.792101. Epub 2009 Feb 23. Circulation. 2009. PMID: 19237663 Free PMC article.
Genetic loss of insulin receptors worsens cardiac efficiency in diabetes.
Bugger H, Riehle C, Jaishy B, Wende AR, Tuinei J, Chen D, Soto J, Pires KM, Boudina S, Theobald HA, Luptak I, Wayment B, Wang X, Litwin SE, Weimer BC, Abel ED. Bugger H, et al. Among authors: abel ed. J Mol Cell Cardiol. 2012 May;52(5):1019-26. doi: 10.1016/j.yjmcc.2012.02.001. Epub 2012 Feb 9. J Mol Cell Cardiol. 2012. PMID: 22342406 Free PMC article.
Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity.
Boudina S, Sena S, Sloan C, Tebbi A, Han YH, O'Neill BT, Cooksey RC, Jones D, Holland WL, McClain DA, Abel ED. Boudina S, et al. Among authors: abel ed. Endocrinology. 2012 Jun;153(6):2677-88. doi: 10.1210/en.2011-2147. Epub 2012 Apr 17. Endocrinology. 2012. PMID: 22510273 Free PMC article.
Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes.
Wende AR, O'Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, McCrory MA, Nye BG, Benavides GA, Darley-Usmar VM, Shioi T, Weimer BC, Abel ED. Wende AR, et al. Among authors: abel ed. Mol Cell Biol. 2015 Mar;35(5):831-46. doi: 10.1128/MCB.01109-14. Epub 2014 Dec 22. Mol Cell Biol. 2015. PMID: 25535334 Free PMC article.
Insulin Signaling and Heart Failure.
Riehle C, Abel ED. Riehle C, et al. Among authors: abel ed. Circ Res. 2016 Apr 1;118(7):1151-69. doi: 10.1161/CIRCRESAHA.116.306206. Circ Res. 2016. PMID: 27034277 Free PMC article. Review.
287 results