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Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease.
Oliveira LMA, Gasser T, Edwards R, Zweckstetter M, Melki R, Stefanis L, Lashuel HA, Sulzer D, Vekrellis K, Halliday GM, Tomlinson JJ, Schlossmacher M, Jensen PH, Schulze-Hentrich J, Riess O, Hirst WD, El-Agnaf O, Mollenhauer B, Lansbury P, Outeiro TF. Oliveira LMA, et al. Among authors: hirst wd. NPJ Parkinsons Dis. 2021 Jul 26;7(1):65. doi: 10.1038/s41531-021-00203-9. NPJ Parkinsons Dis. 2021. PMID: 34312398 Free PMC article. Review.
Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein.
Patterson JR, Hirst WD, Howe JW, Russell CP, Cole-Strauss A, Kemp CJ, Duffy MF, Lamp J, Umstead A, Kubik M, Stoll AC, Vega IE, Steece-Collier K, Chen Y, Campbell AC, Nezich CL, Glajch KE, Sortwell CE. Patterson JR, et al. Among authors: hirst wd. NPJ Parkinsons Dis. 2022 May 24;8(1):61. doi: 10.1038/s41531-022-00322-x. NPJ Parkinsons Dis. 2022. PMID: 35610264 Free PMC article.
Perspective on the current state of the LRRK2 field.
Taymans JM, Fell M, Greenamyre T, Hirst WD, Mamais A, Padmanabhan S, Peter I, Rideout H, Thaler A. Taymans JM, et al. Among authors: hirst wd. NPJ Parkinsons Dis. 2023 Jul 1;9(1):104. doi: 10.1038/s41531-023-00544-7. NPJ Parkinsons Dis. 2023. PMID: 37393318 Free PMC article. Review.
The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release.
Apicco DJ, Shlevkov E, Nezich CL, Tran DT, Guilmette E, Nicholatos JW, Bantle CM, Chen Y, Glajch KE, Abraham NA, Dang LT, Kaynor GC, Tsai EA, Nguyen KH, Groot J, Liu Y, Weihofen A, Hurt JA, Runz H, Hirst WD. Apicco DJ, et al. Among authors: hirst wd. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2006476118. doi: 10.1073/pnas.2006476118. Proc Natl Acad Sci U S A. 2021. PMID: 33443159 Free PMC article.
G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.
Volpicelli-Daley LA, Abdelmotilib H, Liu Z, Stoyka L, Daher JP, Milnerwood AJ, Unni VK, Hirst WD, Yue Z, Zhao HT, Fraser K, Kennedy RE, West AB. Volpicelli-Daley LA, et al. Among authors: hirst wd. J Neurosci. 2016 Jul 13;36(28):7415-27. doi: 10.1523/JNEUROSCI.3642-15.2016. J Neurosci. 2016. PMID: 27413152 Free PMC article.
85 results