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Dopamine-dependent early synaptic and motor dysfunctions induced by α-synuclein in the nigrostriatal circuit.
Tozzi A, Sciaccaluga M, Loffredo V, Megaro A, Ledonne A, Cardinale A, Federici M, Bellingacci L, Paciotti S, Ferrari E, La Rocca A, Martini A, Mercuri NB, Gardoni F, Picconi B, Ghiglieri V, De Leonibus E, Calabresi P. Tozzi A, et al. Among authors: paciotti s. Brain. 2021 Dec 16;144(11):3477-3491. doi: 10.1093/brain/awab242. Brain. 2021. PMID: 34297092 Free PMC article.
Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease.
Parnetti L, Chiasserini D, Persichetti E, Eusebi P, Varghese S, Qureshi MM, Dardis A, Deganuto M, De Carlo C, Castrioto A, Balducci C, Paciotti S, Tambasco N, Bembi B, Bonanni L, Onofrj M, Rossi A, Beccari T, El-Agnaf O, Calabresi P. Parnetti L, et al. Among authors: paciotti s. Mov Disord. 2014 Jul;29(8):1019-27. doi: 10.1002/mds.25772. Epub 2014 Jan 16. Mov Disord. 2014. PMID: 24436092 Free PMC article.
Characterization of Brain Lysosomal Activities in GBA-Related and Sporadic Parkinson's Disease and Dementia with Lewy Bodies.
Moors TE, Paciotti S, Ingrassia A, Quadri M, Breedveld G, Tasegian A, Chiasserini D, Eusebi P, Duran-Pacheco G, Kremer T, Calabresi P, Bonifati V, Parnetti L, Beccari T, van de Berg WDJ. Moors TE, et al. Among authors: paciotti s. Mol Neurobiol. 2019 Feb;56(2):1344-1355. doi: 10.1007/s12035-018-1090-0. Epub 2018 Jun 8. Mol Neurobiol. 2019. PMID: 29948939 Free PMC article.
Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration.
Durante V, de Iure A, Loffredo V, Vaikath N, De Risi M, Paciotti S, Quiroga-Varela A, Chiasserini D, Mellone M, Mazzocchetti P, Calabrese V, Campanelli F, Mechelli A, Di Filippo M, Ghiglieri V, Picconi B, El-Agnaf OM, De Leonibus E, Gardoni F, Tozzi A, Calabresi P. Durante V, et al. Among authors: paciotti s. Brain. 2019 May 1;142(5):1365-1385. doi: 10.1093/brain/awz065. Brain. 2019. PMID: 30927362 Free article.
CSF and blood biomarkers for Parkinson's disease.
Parnetti L, Gaetani L, Eusebi P, Paciotti S, Hansson O, El-Agnaf O, Mollenhauer B, Blennow K, Calabresi P. Parnetti L, et al. Among authors: paciotti s. Lancet Neurol. 2019 Jun;18(6):573-586. doi: 10.1016/S1474-4422(19)30024-9. Epub 2019 Apr 10. Lancet Neurol. 2019. PMID: 30981640 Review.
The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson's disease patients.
Nuzzo T, Punzo D, Devoto P, Rosini E, Paciotti S, Sacchi S, Li Q, Thiolat ML, Véga C, Carella M, Carta M, Gardoni F, Calabresi P, Pollegioni L, Bezard E, Parnetti L, Errico F, Usiello A. Nuzzo T, et al. Among authors: paciotti s. Sci Rep. 2019 Jun 20;9(1):8898. doi: 10.1038/s41598-019-45419-1. Sci Rep. 2019. PMID: 31222058 Free PMC article.
42 results