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Structural studies and biological evaluation of T30695 variants modified with single chiral glycerol-T reveal the importance of LEDGF/p75 for the aptamer anti-HIV-integrase activities.
Rivieccio E, Tartaglione L, Esposito V, Dell'Aversano C, Koneru PC, Scuotto M, Virgilio A, Mayol L, Kvaratskhelia M, Varra M. Rivieccio E, et al. Among authors: koneru pc. Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):351-361. doi: 10.1016/j.bbagen.2018.11.001. Epub 2018 Nov 7. Biochim Biophys Acta Gen Subj. 2019. PMID: 30414444
A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.
Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. Patel D, et al. Among authors: koneru pc. J Biol Chem. 2016 Nov 4;291(45):23569-23577. doi: 10.1074/jbc.M116.753384. Epub 2016 Sep 19. J Biol Chem. 2016. PMID: 27645997 Free PMC article.
An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors.
Wilson TA, Koneru PC, Rebensburg SV, Lindenberger JJ, Kobe MJ, Cockroft NT, Adu-Ampratwum D, Larue RC, Kvaratskhelia M, Fuchs JR. Wilson TA, et al. Among authors: koneru pc. ACS Med Chem Lett. 2019 Jan 30;10(2):215-220. doi: 10.1021/acsmedchemlett.8b00633. eCollection 2019 Feb 14. ACS Med Chem Lett. 2019. PMID: 30783506 Free PMC article.
Identification and Optimization of a Novel HIV-1 Integrase Inhibitor.
Adu-Ampratwum D, Pan Y, Koneru PC, Antwi J, Hoyte AC, Kessl J, Griffin PR, Kvaratskhelia M, Fuchs JR, Larue RC. Adu-Ampratwum D, et al. Among authors: koneru pc. ACS Omega. 2022 Jan 24;7(5):4482-4491. doi: 10.1021/acsomega.1c06378. eCollection 2022 Feb 8. ACS Omega. 2022. PMID: 35155940 Free PMC article.
Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors.
Esposito F, Sechi M, Pala N, Sanna A, Koneru PC, Kvaratskhelia M, Naesens L, Corona A, Grandi N, di Santo R, D'Amore VM, Di Leva FS, Novellino E, Cosconati S, Tramontano E. Esposito F, et al. Among authors: koneru pc. Antiviral Res. 2020 Feb;174:104671. doi: 10.1016/j.antiviral.2019.104671. Epub 2019 Dec 5. Antiviral Res. 2020. PMID: 31812637
15 results