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Bifunctional modalities for repurposing protein function.
Modell AE, Lai S, Nguyen TM, Choudhary A. Modell AE, et al. Among authors: choudhary a. Cell Chem Biol. 2021 Jul 15;28(7):1081-1089. doi: 10.1016/j.chembiol.2021.06.005. Cell Chem Biol. 2021. PMID: 34270935 Free article. Review.
Phosphorylation-Inducing Chimeric Small Molecules.
Siriwardena SU, Munkanatta Godage DNP, Shoba VM, Lai S, Shi M, Wu P, Chaudhary SK, Schreiber SL, Choudhary A. Siriwardena SU, et al. Among authors: choudhary a. J Am Chem Soc. 2020 Aug 19;142(33):14052-14057. doi: 10.1021/jacs.0c05537. Epub 2020 Aug 4. J Am Chem Soc. 2020. PMID: 32787262
Chemical and optical control of CRISPR-associated nucleases.
Modell AE, Siriwardena SU, Shoba VM, Li X, Choudhary A. Modell AE, et al. Among authors: choudhary a. Curr Opin Chem Biol. 2021 Feb;60:113-121. doi: 10.1016/j.cbpa.2020.10.003. Epub 2020 Nov 27. Curr Opin Chem Biol. 2021. PMID: 33253976 Review.
CRISPR-based therapeutics: current challenges and future applications.
Modell AE, Lim D, Nguyen TM, Sreekanth V, Choudhary A. Modell AE, et al. Among authors: choudhary a. Trends Pharmacol Sci. 2022 Feb;43(2):151-161. doi: 10.1016/j.tips.2021.10.012. Epub 2021 Dec 21. Trends Pharmacol Sci. 2022. PMID: 34952739 Free PMC article. Review.
Rational Design of Silicon-Based Zinc Ionophores.
Yamada K, Deb A, Shoba VM, Lim D, Maji B, Modell AE, Choudhary A. Yamada K, et al. Among authors: choudhary a. Angew Chem Int Ed Engl. 2022 Jun 7;61(23):e202201698. doi: 10.1002/anie.202201698. Epub 2022 Apr 6. Angew Chem Int Ed Engl. 2022. PMID: 35385189 Free PMC article.
Synthetic Reprogramming of Kinases Expands Cellular Activities of Proteins.
Shoba VM, Munkanatta Godage DNP, Chaudhary SK, Deb A, Siriwardena SU, Choudhary A. Shoba VM, et al. Among authors: choudhary a. Angew Chem Int Ed Engl. 2022 Jul 18;61(29):e202202770. doi: 10.1002/anie.202202770. Epub 2022 May 31. Angew Chem Int Ed Engl. 2022. PMID: 35641438 Free PMC article.
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules.
Lim D, Zhou Q, Cox KJ, Law BK, Lee M, Kokkonda P, Sreekanth V, Pergu R, Chaudhary SK, Gangopadhyay SA, Maji B, Lai S, Amako Y, Thompson DB, Subramanian HKK, Mesleh MF, Dančík V, Clemons PA, Wagner BK, Woo CM, Church GM, Choudhary A. Lim D, et al. Among authors: choudhary a. Nat Cell Biol. 2022 Dec;24(12):1766-1775. doi: 10.1038/s41556-022-01005-8. Epub 2022 Nov 17. Nat Cell Biol. 2022. PMID: 36396978 Free PMC article.
Proximity-inducing modalities: the past, present, and future.
Singh S, Tian W, Severance ZC, Chaudhary SK, Anokhina V, Mondal B, Pergu R, Singh P, Dhawa U, Singha S, Choudhary A. Singh S, et al. Among authors: choudhary a. Chem Soc Rev. 2023 Aug 14;52(16):5485-5515. doi: 10.1039/d2cs00943a. Chem Soc Rev. 2023. PMID: 37477631 Review.
Proteolysis-targeting chimeras with reduced off-targets.
Nguyen TM, Sreekanth V, Deb A, Kokkonda P, Tiwari PK, Donovan KA, Shoba V, Chaudhary SK, Mercer JAM, Lai S, Sadagopan A, Jan M, Fischer ES, Liu DR, Ebert BL, Choudhary A. Nguyen TM, et al. Among authors: choudhary a. Nat Chem. 2024 Feb;16(2):218-228. doi: 10.1038/s41557-023-01379-8. Epub 2023 Dec 18. Nat Chem. 2024. PMID: 38110475 Free PMC article.
1,091 results