Wu Y - Search Results

1

Picomole-Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer.

Sangouard G, Zorzi A, Wu Y, Ehret E, Schüttel M, Kale S, Díaz-Perlas C, Vesin J, Bortoli Chapalay J, Turcatti G, Heinis C. Sangouard G, et al. Among authors: wu y. Angew Chem Int Ed Engl. 2021 Sep 27;60(40):21702-21707. doi: 10.1002/anie.202107815. Epub 2021 Aug 25. Angew Chem Int Ed Engl. 2021. PMID: 34268864

2

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands.

Kale SS, Bergeron-Brlek M, Wu Y, Kumar MG, Pham MV, Bortoli J, Vesin J, Kong XD, Machado JF, Deyle K, Gonschorek P, Turcatti G, Cendron L, Angelini A, Heinis C. Kale SS, et al. Among authors: wu y. Sci Adv. 2019 Aug 21;5(8):eaaw2851. doi: 10.1126/sciadv.aaw2851. eCollection 2019 Aug. Sci Adv. 2019. PMID: 31457083 Free PMC article.

3

A releasable disulfide-linked peptide tag facilitates the synthesis and purification of short peptides.

Wu Y , Zorzi A , Williams J , Heinis C . Wu Y , et al. Chem Commun (Camb). 2020 Mar 7;56(19):2917-2920. doi: 10.1039/c9cc09247a. Epub 2020 Feb 10. Chem Commun (Camb). 2020. PMID: 32037436

4

Development of Selective FXIa Inhibitors Based on Cyclic Peptides and Their Application for Safe Anticoagulation.

Carle V, Wu Y, Mukherjee R, Kong XD, Rogg C, Laurent Q, Cecere E, Villequey C, Konakalla MS, Maric T, Lamers C, Díaz-Perlas C, Butler K, Goto J, Stegmayr B, Heinis C. Carle V, et al. Among authors: wu y. J Med Chem. 2021 May 27;64(10):6802-6813. doi: 10.1021/acs.jmedchem.1c00056. Epub 2021 May 11. J Med Chem. 2021. PMID: 33974422

5

Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.

Lau YH, Wu Y, Rossmann M, Tan BX, de Andrade P, Tan YS, Verma C, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR. Lau YH, et al. Among authors: wu y. Angew Chem Int Ed Engl. 2015 Dec 14;54(51):15410-3. doi: 10.1002/anie.201508416. Epub 2015 Nov 2. Angew Chem Int Ed Engl. 2015. PMID: 26768531 Free PMC article.

6

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.

Wiedmann MM, Tan YS, Wu Y, Aibara S, Xu W, Sore HF, Verma CS, Itzhaki L, Stewart M, Brenton JD, Spring DR. Wiedmann MM, et al. Among authors: wu y. Angew Chem Int Ed Engl. 2017 Jan 9;56(2):524-529. doi: 10.1002/anie.201609427. Epub 2016 Dec 5. Angew Chem Int Ed Engl. 2017. PMID: 27918136 Free PMC article.

7

Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.

Wu Y, Villa F, Maman J, Lau YH, Dobnikar L, Simon AC, Labib K, Spring DR, Pellegrini L. Wu Y, et al. Angew Chem Int Ed Engl. 2017 Oct 9;56(42):12866-12872. doi: 10.1002/anie.201705611. Epub 2017 Sep 7. Angew Chem Int Ed Engl. 2017. PMID: 28815832

8

Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.

Charoenpattarapreeda J, Tan YS, Iegre J, Walsh SJ, Fowler E, Eapen RS, Wu Y, Sore HF, Verma CS, Itzhaki L, Spring DR. Charoenpattarapreeda J, et al. Among authors: wu y. Chem Commun (Camb). 2019 Jul 14;55(55):7914-7917. doi: 10.1039/c9cc04022f. Epub 2019 Jun 21. Chem Commun (Camb). 2019. PMID: 31225847

9

Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides.

Wu Y, Kaur A, Fowler E, Wiedmann MM, Young R, Galloway WRJD, Olsen L, Sore HF, Chattopadhyay A, Kwan TT, Xu W, Walsh SJ, de Andrade P, Janecek M, Arumugam S, Itzhaki LS, Lau YH, Spring DR. Wu Y, et al. ACS Chem Biol. 2019 Mar 15;14(3):526-533. doi: 10.1021/acschembio.9b00063. Epub 2019 Feb 7. ACS Chem Biol. 2019. PMID: 30702850

10

Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling.

Wu Y, Olsen LB, Lau YH, Jensen CH, Rossmann M, Baker YR, Sore HF, Collins S, Spring DR. Wu Y, et al. Chembiochem. 2016 Apr 15;17(8):689-92. doi: 10.1002/cbic.201500648. Epub 2016 Mar 16. Chembiochem. 2016. PMID: 26919579 Free PMC article.

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