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A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects.
Qian H, Chen Q, Liang L, Zou Y, Pu H, Xin L, Song R, Li T, Zhu H, Wang Y, Tian G, Shen J, Jiang H, Yu C, Wang Z, Jia J. Qian H, et al. Among authors: tian g. Drug Des Devel Ther. 2021 Jul 6;15:2947-2959. doi: 10.2147/DDDT.S308610. eCollection 2021. Drug Des Devel Ther. 2021. PMID: 34262260 Free PMC article. Clinical Trial.
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects.
Qian HJ, Wang Y, Zhang MQ, Xie YC, Wu QQ, Liang LY, Cao Y, Duan HQ, Tian GH, Ma J, Zhang ZB, Li N, Jia JY, Zhang J, Aisa HA, Shen JS, Yu C, Jiang HL, Zhang WH, Wang Z, Liu GY. Qian HJ, et al. Acta Pharmacol Sin. 2022 Dec;43(12):3130-3138. doi: 10.1038/s41401-022-00895-6. Epub 2022 Mar 16. Acta Pharmacol Sin. 2022. PMID: 35296780 Free PMC article.
Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.
Wang Z, Jiang X, Zhang X, Tian G, Yang R, Wu J, Zou X, Liu Z, Yang X, Wu C, Shi J, Li J, Suo J, Wang Y, Zhang R, Xu Z, Gong X, He Y, Zhu W, Aisa HA, Jiang H, Xu Y, Shen J. Wang Z, et al. Among authors: tian g. J Med Chem. 2019 May 23;62(10):4979-4990. doi: 10.1021/acs.jmedchem.9b00123. Epub 2019 May 8. J Med Chem. 2019. PMID: 31021628
The selectivity and potency of the new PDE5 inhibitor TPN729MA.
Wang Z, Zhu D, Yang X, Li J, Jiang X, Tian G, Terrett NK, Jin J, Wu H, He Q, Yang B, Shen J. Wang Z, et al. Among authors: tian g. J Sex Med. 2013 Nov;10(11):2790-7. doi: 10.1111/jsm.12285. Epub 2013 Aug 12. J Sex Med. 2013. PMID: 23937247
3,309 results