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Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.
Chrysostomou S, Roy R, Prischi F, Thamlikitkul L, Chapman KL, Mufti U, Peach R, Ding L, Hancock D, Moore C, Molina-Arcas M, Mauri F, Pinato DJ, Abrahams JM, Ottaviani S, Castellano L, Giamas G, Pascoe J, Moonamale D, Pirrie S, Gaunt C, Billingham L, Steven NM, Cullen M, Hrouda D, Winkler M, Post J, Cohen P, Salpeter SJ, Bar V, Zundelevich A, Golan S, Leibovici D, Lara R, Klug DR, Yaliraki SN, Barahona M, Wang Y, Downward J, Skehel JM, Ali MMU, Seckl MJ, Pardo OE. Chrysostomou S, et al. Among authors: skehel jm. Sci Transl Med. 2021 Jul 14;13(602):eaba4627. doi: 10.1126/scitranslmed.aba4627. Sci Transl Med. 2021. PMID: 34261798 Free PMC article.
Human CDK18 promotes replication stress signaling and genome stability.
Barone G, Staples CJ, Ganesh A, Patterson KW, Bryne DP, Myers KN, Patil AA, Eyers CE, Maslen S, Skehel JM, Eyers PA, Collis SJ. Barone G, et al. Among authors: skehel jm. Nucleic Acids Res. 2016 Oct 14;44(18):8772-8785. doi: 10.1093/nar/gkw615. Epub 2016 Jul 5. Nucleic Acids Res. 2016. PMID: 27382066 Free PMC article.
The Structure of the R2TP Complex Defines a Platform for Recruiting Diverse Client Proteins to the HSP90 Molecular Chaperone System.
Rivera-Calzada A, Pal M, Muñoz-Hernández H, Luque-Ortega JR, Gil-Carton D, Degliesposti G, Skehel JM, Prodromou C, Pearl LH, Llorca O. Rivera-Calzada A, et al. Among authors: skehel jm. Structure. 2017 Jul 5;25(7):1145-1152.e4. doi: 10.1016/j.str.2017.05.016. Epub 2017 Jun 22. Structure. 2017. PMID: 28648606 Free PMC article.
85 results