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Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.
Chrysostomou S, Roy R, Prischi F, Thamlikitkul L, Chapman KL, Mufti U, Peach R, Ding L, Hancock D, Moore C, Molina-Arcas M, Mauri F, Pinato DJ, Abrahams JM, Ottaviani S, Castellano L, Giamas G, Pascoe J, Moonamale D, Pirrie S, Gaunt C, Billingham L, Steven NM, Cullen M, Hrouda D, Winkler M, Post J, Cohen P, Salpeter SJ, Bar V, Zundelevich A, Golan S, Leibovici D, Lara R, Klug DR, Yaliraki SN, Barahona M, Wang Y, Downward J, Skehel JM, Ali MMU, Seckl MJ, Pardo OE. Chrysostomou S, et al. Among authors: roy r. Sci Transl Med. 2021 Jul 14;13(602):eaba4627. doi: 10.1126/scitranslmed.aba4627. Sci Transl Med. 2021. PMID: 34261798 Free PMC article.
Chromosomal instability determines taxane response.
Swanton C, Nicke B, Schuett M, Eklund AC, Ng C, Li Q, Hardcastle T, Lee A, Roy R, East P, Kschischo M, Endesfelder D, Wylie P, Kim SN, Chen JG, Howell M, Ried T, Habermann JK, Auer G, Brenton JD, Szallasi Z, Downward J. Swanton C, et al. Among authors: roy r. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8671-6. doi: 10.1073/pnas.0811835106. Epub 2009 May 19. Proc Natl Acad Sci U S A. 2009. PMID: 19458043 Free PMC article.
Targeting autophagy sensitises lung cancer cells to Src family kinase inhibitors.
Rupniewska E, Roy R, Mauri FA, Liu X, Kaliszczak M, Bellezza G, Cagini L, Barbareschi M, Ferrero S, Tommasi AM, Aboagye E, Seckl MJ, Pardo OE. Rupniewska E, et al. Among authors: roy r. Oncotarget. 2018 Jun 8;9(44):27346-27362. doi: 10.18632/oncotarget.25213. eCollection 2018 Jun 8. Oncotarget. 2018. PMID: 29937990 Free PMC article.
ATR and CDK4/6 inhibition target the growth of methotrexate-resistant choriocarcinoma.
Georgiou M, Ntavelou P, Stokes W, Roy R, Maher GJ, Stoilova T, Choo JAMY, Rakhit CP, Martins M, Ajuh P, Horowitz N, Berkowitz RS, Elias K, Seckl MJ, Pardo OE. Georgiou M, et al. Among authors: roy r. Oncogene. 2022 Apr;41(18):2540-2554. doi: 10.1038/s41388-022-02251-8. Epub 2022 Mar 18. Oncogene. 2022. PMID: 35301407 Free PMC article.
3,523 results