Downward J - Search Results

1

Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.

Chrysostomou S, Roy R, Prischi F, Thamlikitkul L, Chapman KL, Mufti U, Peach R, Ding L, Hancock D, Moore C, Molina-Arcas M, Mauri F, Pinato DJ, Abrahams JM, Ottaviani S, Castellano L, Giamas G, Pascoe J, Moonamale D, Pirrie S, Gaunt C, Billingham L, Steven NM, Cullen M, Hrouda D, Winkler M, Post J, Cohen P, Salpeter SJ, Bar V, Zundelevich A, Golan S, Leibovici D, Lara R, Klug DR, Yaliraki SN, Barahona M, Wang Y, Downward J, Skehel JM, Ali MMU, Seckl MJ, Pardo OE. Chrysostomou S, et al. Among authors: downward j. Sci Transl Med. 2021 Jul 14;13(602):eaba4627. doi: 10.1126/scitranslmed.aba4627. Sci Transl Med. 2021. PMID: 34261798 Free PMC article.

2

Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis.

Pardo OE, Arcaro A, Salerno G, Raguz S, Downward J, Seckl MJ. Pardo OE, et al. Among authors: downward j. J Biol Chem. 2002 Apr 5;277(14):12040-6. doi: 10.1074/jbc.M109006200. Epub 2002 Jan 28. J Biol Chem. 2002. PMID: 11815602 Free article. Retracted.

3

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.

Marani M, Tenev T, Hancock D, Downward J, Lemoine NR. Marani M, et al. Among authors: downward j. Mol Cell Biol. 2002 Jun;22(11):3577-89. doi: 10.1128/MCB.22.11.3577-3589.2002. Mol Cell Biol. 2002. PMID: 11997495 Free PMC article.

4

Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells.

Pardo OE, Lesay A, Arcaro A, Lopes R, Ng BL, Warne PH, McNeish IA, Tetley TD, Lemoine NR, Mehmet H, Seckl MJ, Downward J. Pardo OE, et al. Among authors: downward j. Mol Cell Biol. 2003 Nov;23(21):7600-10. doi: 10.1128/MCB.23.21.7600-7610.2003. Mol Cell Biol. 2003. PMID: 14560006 Free PMC article.

5

Role of Bim in the survival pathway induced by Raf in epithelial cells.

Marani M, Hancock D, Lopes R, Tenev T, Downward J, Lemoine NR. Marani M, et al. Among authors: downward j. Oncogene. 2004 Apr 1;23(14):2431-41. doi: 10.1038/sj.onc.1207364. Oncogene. 2004. PMID: 14676826

6

CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness.

Michl P, Ramjaun AR, Pardo OE, Warne PH, Wagner M, Poulsom R, D'Arrigo C, Ryder K, Menke A, Gress T, Downward J. Michl P, et al. Among authors: downward j. Cancer Cell. 2005 Jun;7(6):521-32. doi: 10.1016/j.ccr.2005.05.018. Cancer Cell. 2005. PMID: 15950902 Free article.

7

Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling.

Khanzada UK, Pardo OE, Meier C, Downward J, Seckl MJ, Arcaro A. Khanzada UK, et al. Among authors: downward j. Oncogene. 2006 Feb 9;25(6):877-87. doi: 10.1038/sj.onc.1209117. Oncogene. 2006. PMID: 16170339

8

FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2.

Pardo OE, Wellbrock C, Khanzada UK, Aubert M, Arozarena I, Davidson S, Bowen F, Parker PJ, Filonenko VV, Gout IT, Sebire N, Marais R, Downward J, Seckl MJ. Pardo OE, et al. Among authors: downward j. EMBO J. 2006 Jul 12;25(13):3078-88. doi: 10.1038/sj.emboj.7601198. Epub 2006 Jun 29. EMBO J. 2006. PMID: 16810323 Free PMC article.

9

Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.

Swanton C, Marani M, Pardo O, Warne PH, Kelly G, Sahai E, Elustondo F, Chang J, Temple J, Ahmed AA, Brenton JD, Downward J, Nicke B. Swanton C, et al. Among authors: downward j. Cancer Cell. 2007 Jun;11(6):498-512. doi: 10.1016/j.ccr.2007.04.011. Cancer Cell. 2007. PMID: 17560332 Free article.

10

Chromosomal instability determines taxane response.

Swanton C, Nicke B, Schuett M, Eklund AC, Ng C, Li Q, Hardcastle T, Lee A, Roy R, East P, Kschischo M, Endesfelder D, Wylie P, Kim SN, Chen JG, Howell M, Ried T, Habermann JK, Auer G, Brenton JD, Szallasi Z, Downward J. Swanton C, et al. Among authors: downward j. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8671-6. doi: 10.1073/pnas.0811835106. Epub 2009 May 19. Proc Natl Acad Sci U S A. 2009. PMID: 19458043 Free PMC article.

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