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Design, synthesis, biological evaluation, and modeling studies of novel conformationally-restricted analogues of sorafenib as selective kinase-inhibitory antiproliferative agents against hepatocellular carcinoma cells.
Sbenati RM, Zaraei SO, El-Gamal MI, Anbar HS, Tarazi H, Zoghbor MM, Mohamood NA, Khakpour MM, Zaher DM, Omar HA, Alach NN, Shehata MK, El-Gamal R. Sbenati RM, et al. Among authors: shehata mk. Eur J Med Chem. 2021 Jan 15;210:113081. doi: 10.1016/j.ejmech.2020.113081. Epub 2020 Dec 4. Eur J Med Chem. 2021. PMID: 33310290
Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents.
Ullah S, El-Gamal MI, El-Gamal R, Pelletier J, Sévigny J, Shehata MK, Anbar HS, Iqbal J. Ullah S, et al. Among authors: shehata mk. Eur J Med Chem. 2021 May 5;217:113339. doi: 10.1016/j.ejmech.2021.113339. Epub 2021 Mar 10. Eur J Med Chem. 2021. PMID: 33744686
Design and synthesis of new quinoline derivatives as selective C-RAF kinase inhibitors with potent anticancer activity.
Zaraei SO, Al-Ach NN, Anbar HS, El-Gamal R, Tarazi H, Tokatly RT, Kalla RR, Munther MA, Wahba MM, Alshihabi AM, Shehata MK, Sbenati RM, Shahin AI, El-Awady R, Al-Tel TH, El-Gamal MI. Zaraei SO, et al. Among authors: shehata mk. Eur J Med Chem. 2022 Aug 5;238:114434. doi: 10.1016/j.ejmech.2022.114434. Epub 2022 May 5. Eur J Med Chem. 2022. PMID: 35551038
Design, synthesis, and biological evaluation of a new series of pyrazole derivatives: Discovery of potent and selective JNK3 kinase inhibitors.
Abu Rabah RR, Sebastian A, Vunnam S, Sultan S, Tarazi H, Anbar HS, Shehata MK, Zaraei SO, Elgendy SM, Al Shamma SA, Omar HA, Al-Tel TH, El-Gamal MI. Abu Rabah RR, et al. Among authors: shehata mk. Bioorg Med Chem. 2022 Sep 1;69:116894. doi: 10.1016/j.bmc.2022.116894. Epub 2022 Jun 20. Bioorg Med Chem. 2022. PMID: 35764033
12 results