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201 results

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Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping.
Chen Z, Mori W, Rong J, Schafroth MA, Shao T, Van RS, Ogasawara D, Yamasaki T, Hiraishi A, Hatori A, Chen J, Zhang Y, Hu K, Fujinaga M, Sun J, Yu Q, Collier TL, Shao Y, Cravatt BF, Josephson L, Zhang MR, Liang SH. Chen Z, et al. Among authors: josephson l. Acta Pharm Sin B. 2021 Jun;11(6):1686-1695. doi: 10.1016/j.apsb.2021.01.021. Epub 2021 Apr 1. Acta Pharm Sin B. 2021. PMID: 34221877 Free PMC article.
Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton.
Chen Z, Mori W, Deng X, Cheng R, Ogasawara D, Zhang G, Schafroth MA, Dahl K, Fu H, Hatori A, Shao T, Zhang Y, Yamasaki T, Zhang X, Rong J, Yu Q, Hu K, Fujinaga M, Xie L, Kumata K, Gou Y, Chen J, Gu S, Bao L, Wang L, Collier TL, Vasdev N, Shao Y, Ma JA, Cravatt BF, Fowler C, Josephson L, Zhang MR, Liang SH. Chen Z, et al. Among authors: josephson l. J Med Chem. 2019 Apr 11;62(7):3336-3353. doi: 10.1021/acs.jmedchem.8b01778. Epub 2019 Mar 21. J Med Chem. 2019. PMID: 30829483 Free PMC article.
Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes.
Chen Z, Mori W, Fu H, Schafroth MA, Hatori A, Shao T, Zhang G, Van RS, Zhang Y, Hu K, Fujinaga M, Wang L, Belov V, Ogasawara D, Giffenig P, Deng X, Rong J, Yu Q, Zhang X, Papisov MI, Shao Y, Collier TL, Ma JA, Cravatt BF, Josephson L, Zhang MR, Liang SH. Chen Z, et al. Among authors: josephson l. J Med Chem. 2019 Oct 10;62(19):8866-8872. doi: 10.1021/acs.jmedchem.9b00936. Epub 2019 Sep 26. J Med Chem. 2019. PMID: 31518130 Free PMC article.
Synthesis and preliminary evaluation of novel 11C-labeled GluN2B-selective NMDA receptor negative allosteric modulators.
Sun JY, Kumata K, Chen Z, Zhang YD, Chen JH, Hatori A, Fu HL, Rong J, Deng XY, Yamasaki T, Xie L, Hu K, Fujinaga M, Yu QZ, Shao T, Collier TL, Josephson L, Shao YH, Du YF, Wang L, Xu H, Zhang MR, Liang SH. Sun JY, et al. Among authors: josephson l. Acta Pharmacol Sin. 2021 Mar;42(3):491-498. doi: 10.1038/s41401-020-0456-9. Epub 2020 Jul 13. Acta Pharmacol Sin. 2021. PMID: 32661351 Free PMC article.
Recent developments on PET radiotracers for TSPO and their applications in neuroimaging.
Zhang L, Hu K, Shao T, Hou L, Zhang S, Ye W, Josephson L, Meyer JH, Zhang MR, Vasdev N, Wang J, Xu H, Wang L, Liang SH. Zhang L, et al. Among authors: josephson l. Acta Pharm Sin B. 2021 Feb;11(2):373-393. doi: 10.1016/j.apsb.2020.08.006. Epub 2020 Aug 25. Acta Pharm Sin B. 2021. PMID: 33643818 Free PMC article. Review.
Imaging Autotaxin In Vivo with 18F-Labeled Positron Emission Tomography Ligands.
Deng X, Salgado-Polo F, Shao T, Xiao Z, Van R, Chen J, Rong J, Haider A, Shao Y, Josephson L, Perrakis A, Liang SH. Deng X, et al. Among authors: josephson l. J Med Chem. 2021 Oct 28;64(20):15053-15068. doi: 10.1021/acs.jmedchem.1c00913. Epub 2021 Oct 18. J Med Chem. 2021. PMID: 34662125
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models.
Shao T, Chen Z, Rong J, Belov V, Chen J, Jeyarajan A, Deng X, Fu H, Yu Q, Rwema SH, Lin W, Papisov M, Josephson L, Chung RT, Liang SH. Shao T, et al. Among authors: josephson l. Acta Pharm Sin B. 2022 Jan;12(1):308-315. doi: 10.1016/j.apsb.2021.07.007. Epub 2021 Jul 17. Acta Pharm Sin B. 2022. PMID: 35127387 Free PMC article.
A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network.
Cheng R, Fujinaga M, Yang J, Rong J, Haider A, Ogasawara D, Van RS, Shao T, Chen Z, Zhang X, Calderon Leon ER, Zhang Y, Mori W, Kumata K, Yamasaki T, Xie L, Sun S, Wang L, Ran C, Shao Y, Cravatt B, Josephson L, Zhang MR, Liang SH. Cheng R, et al. Among authors: josephson l. Acta Pharmacol Sin. 2022 Nov;43(11):3002-3010. doi: 10.1038/s41401-022-00912-8. Epub 2022 May 5. Acta Pharmacol Sin. 2022. PMID: 35513432 Free PMC article.
Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-Methyl-d-aspartate (NMDA), α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors.
Fu H, Chen Z, Josephson L, Li Z, Liang SH. Fu H, et al. Among authors: josephson l. J Med Chem. 2019 Jan 24;62(2):403-419. doi: 10.1021/acs.jmedchem.8b00714. Epub 2018 Aug 27. J Med Chem. 2019. PMID: 30110164 Free PMC article. Review.
201 results