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Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates.
Cantrelle FX, Loyens A, Trivelli X, Reimann O, Despres C, Gandhi NS, Hackenberger CPR, Landrieu I, Smet-Nocca C. Cantrelle FX, et al. Among authors: loyens a. Front Mol Neurosci. 2021 Jun 17;14:661368. doi: 10.3389/fnmol.2021.661368. eCollection 2021. Front Mol Neurosci. 2021. PMID: 34220449 Free PMC article.
Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.
Danis C, Dupré E, Zejneli O, Caillierez R, Arrial A, Bégard S, Mortelecque J, Eddarkaoui S, Loyens A, Cantrelle FX, Hanoulle X, Rain JC, Colin M, Buée L, Landrieu I. Danis C, et al. Among authors: loyens a. Mol Ther. 2022 Apr 6;30(4):1484-1499. doi: 10.1016/j.ymthe.2022.01.009. Epub 2022 Jan 7. Mol Ther. 2022. PMID: 35007758 Free PMC article.
Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain.
Caillierez R, Bégard S, Lécolle K, Deramecourt V, Zommer N, Dujardin S, Loyens A, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Buée L, Colin M. Caillierez R, et al. Among authors: loyens a. Mol Ther. 2013 Jul;21(7):1358-68. doi: 10.1038/mt.2013.66. Epub 2013 Apr 23. Mol Ther. 2013. PMID: 23609018 Free PMC article.
Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies.
Vingtdeux V, Hamdane M, Loyens A, Gelé P, Drobeck H, Bégard S, Galas MC, Delacourte A, Beauvillain JC, Buée L, Sergeant N. Vingtdeux V, et al. Among authors: loyens a. J Biol Chem. 2007 Jun 22;282(25):18197-18205. doi: 10.1074/jbc.M609475200. Epub 2007 Apr 27. J Biol Chem. 2007. PMID: 17468104 Free article.
We showed recently that the amyloid intracellular domain (AICD), which is released by gamma-secretase cleavage of APP C-terminal fragments (CTFs), is strongly increased in cells treated with alkalizing drugs (Vingtdeux, V., Hamdane, M., Begard, S., Loyens, A., Delac …
We showed recently that the amyloid intracellular domain (AICD), which is released by gamma-secretase cleavage of APP C-terminal fragments ( …
Ectosomes: a new mechanism for non-exosomal secretion of tau protein.
Dujardin S, Bégard S, Caillierez R, Lachaud C, Delattre L, Carrier S, Loyens A, Galas MC, Bousset L, Melki R, Aurégan G, Hantraye P, Brouillet E, Buée L, Colin M. Dujardin S, et al. Among authors: loyens a. PLoS One. 2014 Jun 27;9(6):e100760. doi: 10.1371/journal.pone.0100760. eCollection 2014. PLoS One. 2014. PMID: 24971751 Free PMC article.
48 results