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FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.
Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, Bernstein D, Solow-Cordero DE, Beachy PA, Wandless TJ, Ten Dijke P, Rabinovitch M. Spiekerkoetter E, et al. J Clin Invest. 2013 Aug;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15. J Clin Invest. 2013. PMID: 23867624 Free PMC article.
Current clinical management of pulmonary arterial hypertension.
Zamanian RT, Kudelko KT, Sung YK, Perez VJ, Liu J, Spiekerkoetter E. Zamanian RT, et al. Among authors: spiekerkoetter e. Circ Res. 2014 Jun 20;115(1):131-147. doi: 10.1161/CIRCRESAHA.115.303827. Circ Res. 2014. PMID: 24951763 Free PMC article. Review.
Targeting the Wnt signaling pathways in pulmonary arterial hypertension.
de Jesus Perez V, Yuan K, Alastalo TP, Spiekerkoetter E, Rabinovitch M. de Jesus Perez V, et al. Among authors: spiekerkoetter e. Drug Discov Today. 2014 Aug;19(8):1270-6. doi: 10.1016/j.drudis.2014.06.014. Epub 2014 Jun 20. Drug Discov Today. 2014. PMID: 24955837 Free PMC article. Review.
RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension.
Rhodes CJ, Im H, Cao A, Hennigs JK, Wang L, Sa S, Chen PI, Nickel NP, Miyagawa K, Hopper RK, Tojais NF, Li CG, Gu M, Spiekerkoetter E, Xian Z, Chen R, Zhao M, Kaschwich M, Del Rosario PA, Bernstein D, Zamanian RT, Wu JC, Snyder MP, Rabinovitch M. Rhodes CJ, et al. Among authors: spiekerkoetter e. Am J Respir Crit Care Med. 2015 Aug 1;192(3):356-66. doi: 10.1164/rccm.201408-1528OC. Am J Respir Crit Care Med. 2015. PMID: 26030479 Free PMC article.
Update in Pulmonary Vascular Disease 2016 and 2017.
Brittain EL, Thennapan T, Maron BA, Chan SY, Austin ED, Spiekerkoetter E, Bogaard HJ, Guignabert C, Paulin R, Machado RF, Yu PB. Brittain EL, et al. Among authors: spiekerkoetter e. Am J Respir Crit Care Med. 2018 Jul 1;198(1):13-23. doi: 10.1164/rccm.201801-0062UP. Am J Respir Crit Care Med. 2018. PMID: 29533671 Free PMC article. No abstract available.
A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017.
Kuebler WM, Nicolls MR, Olschewski A, Abe K, Rabinovitch M, Stewart D, Chan SY, Morrell NW, Archer SL, Spiekerkoetter E. Kuebler WM, et al. Among authors: spiekerkoetter e. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L502-L516. doi: 10.1152/ajplung.00150.2018. Epub 2018 Jun 7. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 29877097 Free PMC article. Review.
FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension.
Dannewitz Prosseda S, Tian X, Kuramoto K, Boehm M, Sudheendra D, Miyagawa K, Zhang F, Solow-Cordero D, Saldivar JC, Austin ED, Loyd JE, Wheeler L, Andruska A, Donato M, Wang L, Huebner K, Metzger RJ, Khatri P, Spiekerkoetter E. Dannewitz Prosseda S, et al. Among authors: spiekerkoetter e. Am J Respir Crit Care Med. 2019 Jan 1;199(1):83-98. doi: 10.1164/rccm.201712-2553OC. Am J Respir Crit Care Med. 2019. PMID: 30107138 Free PMC article.
67 results