Zhang M - Search Results

1

Novel MAPK/AKT-impairing germline NRAS variant identified in a melanoma-prone family.

Brown KM, Xu M, Sargen M, Jang H, Zhang M, Zhang T, Zhu B, Jones K, Kim J, Mendoza L, Hayward NK, Tucker MA, Goldstein AM, Yang XR, Stewart DR, Hicks B, Consonni D, Pesatori AC, Fargnoli MC, Peris K, Stratigos A, Menin C, Ghiorzo P, Puig S, Nagore E; MelaNostrum Consortium; Andresson T, Nussinov R, Calista D, Landi MT. Brown KM, et al. Among authors: zhang m, zhang t. Fam Cancer. 2022 Jul;21(3):347-355. doi: 10.1007/s10689-021-00267-9. Epub 2021 Jul 3. Fam Cancer. 2022. PMID: 34215961 Free PMC article.

2

Oncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the Membrane.

Zhang M, Zheng J, Nussinov R, Ma B. Zhang M, et al. Sci Rep. 2016 Sep 15;6:33340. doi: 10.1038/srep33340. Sci Rep. 2016. PMID: 27630059 Free PMC article.

3

Release of Cytochrome C from Bax Pores at the Mitochondrial Membrane.

Zhang M, Zheng J, Nussinov R, Ma B. Zhang M, et al. Sci Rep. 2017 Jun 1;7(1):2635. doi: 10.1038/s41598-017-02825-7. Sci Rep. 2017. PMID: 28572603 Free PMC article.

4

Calmodulin and IQGAP1 activation of PI3Kα and Akt in KRAS, HRAS and NRAS-driven cancers.

Nussinov R, Zhang M, Tsai CJ, Jang H. Nussinov R, et al. Among authors: zhang m. Biochim Biophys Acta Mol Basis Dis. 2018 Jun;1864(6 Pt B):2304-2314. doi: 10.1016/j.bbadis.2017.10.032. Epub 2017 Oct 31. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 29097261 Free article. Review.

5

Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH₂ Domains.

Zhang M, Jang H, Gaponenko V, Nussinov R. Zhang M, et al. Biophys J. 2017 Nov 7;113(9):1956-1967. doi: 10.1016/j.bpj.2017.09.008. Biophys J. 2017. PMID: 29117520 Free PMC article.

6

Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit.

Wang G, Zhang M, Jang H, Lu S, Lin S, Chen G, Nussinov R, Zhang J, Gaponenko V. Wang G, et al. Among authors: zhang m, zhang j. Biochemistry. 2018 Mar 27;57(12):1917-1928. doi: 10.1021/acs.biochem.7b01130. Epub 2018 Mar 19. Biochemistry. 2018. PMID: 29494137 Free PMC article.

7

Experimental and Computational Protocols for Studies of Cross-Seeding Amyloid Assemblies.

Ren B, Hu R, Zhang M, Liu Y, Xu L, Jiang B, Ma J, Ma B, Nussinov R, Zheng J. Ren B, et al. Among authors: zhang m. Methods Mol Biol. 2018;1777:429-447. doi: 10.1007/978-1-4939-7811-3_27. Methods Mol Biol. 2018. PMID: 29744852 Free PMC article.

8

Calmodulin (CaM) Activates PI3Kα by Targeting the "Soft" CaM-Binding Motifs in Both the nSH2 and cSH2 Domains of p85α.

Zhang M, Li Z, Wang G, Jang H, Sacks DB, Zhang J, Gaponenko V, Nussinov R. Zhang M, et al. Among authors: zhang j. J Phys Chem B. 2018 Dec 13;122(49):11137-11146. doi: 10.1021/acs.jpcb.8b05982. Epub 2018 Aug 8. J Phys Chem B. 2018. PMID: 30047727 Free PMC article.

9

Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention.

Nussinov R, Zhang M, Tsai CJ, Liao TJ, Fushman D, Jang H. Nussinov R, et al. Among authors: zhang m. Biophys Rev. 2018 Oct;10(5):1263-1282. doi: 10.1007/s12551-018-0461-0. Epub 2018 Sep 29. Biophys Rev. 2018. PMID: 30269291 Free PMC article. Review.

10

The mechanism of PI3Kα activation at the atomic level.

Zhang M, Jang H, Nussinov R. Zhang M, et al. Chem Sci. 2019 Feb 20;10(12):3671-3680. doi: 10.1039/c8sc04498h. eCollection 2019 Mar 28. Chem Sci. 2019. PMID: 30996962 Free PMC article.

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