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A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.
Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. Leissring MA, et al. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4697-702. doi: 10.1073/pnas.072033799. Epub 2002 Mar 26. Proc Natl Acad Sci U S A. 2002. PMID: 11917117 Free PMC article.
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.
Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Müller UC. Ring S, et al. Among authors: muller uc. J Neurosci. 2007 Jul 18;27(29):7817-26. doi: 10.1523/JNEUROSCI.1026-07.2007. J Neurosci. 2007. PMID: 17634375 Free PMC article.
APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.
Weyer SW, Klevanski M, Delekate A, Voikar V, Aydin D, Hick M, Filippov M, Drost N, Schaller KL, Saar M, Vogt MA, Gass P, Samanta A, Jäschke A, Korte M, Wolfer DP, Caldwell JH, Müller UC. Weyer SW, et al. Among authors: muller uc. EMBO J. 2011 Jun 1;30(11):2266-80. doi: 10.1038/emboj.2011.119. Epub 2011 Apr 26. EMBO J. 2011. PMID: 21522131 Free PMC article.
Hippocampal network oscillations in APP/APLP2-deficient mice.
Zhang X, Herrmann U, Weyer SW, Both M, Müller UC, Korte M, Draguhn A. Zhang X, et al. Among authors: muller uc. PLoS One. 2013 Apr 9;8(4):e61198. doi: 10.1371/journal.pone.0061198. Print 2013. PLoS One. 2013. PMID: 23585881 Free PMC article.
112 results