Hunt H - Search Results

1

An integrated framework for quantifying immune-tumour interactions in a 3D co-culture model.

Al-Hity G, Yang F, Campillo-Funollet E, Greenstein AE, Hunt H, Mampay M, Intabli H, Falcinelli M, Madzvamuse A, Venkataraman C, Flint MS. Al-Hity G, et al. Among authors: hunt h. Commun Biol. 2021 Jun 24;4(1):781. doi: 10.1038/s42003-021-02296-7. Commun Biol. 2021. PMID: 34168276 Free PMC article.

2

Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells.

Greenstein AE, Hunt HJ. Greenstein AE, et al. Oncotarget. 2021 Jun 22;12(13):1243-1255. doi: 10.18632/oncotarget.27989. eCollection 2021 Jun 22. Oncotarget. 2021. PMID: 34194622 Free PMC article.

3

The glucocorticoid receptor modulator relacorilant reverses the immunosuppressive effects of cortisol.

Greenstein AE, Hunt HJ. Greenstein AE, et al. Int Immunopharmacol. 2023 Jul;120:110312. doi: 10.1016/j.intimp.2023.110312. Epub 2023 May 23. Int Immunopharmacol. 2023. PMID: 37230031

4

Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist.

Hunt HJ, Belanoff JK, Walters I, Gourdet B, Thomas J, Barton N, Unitt J, Phillips T, Swift D, Eaton E. Hunt HJ, et al. J Med Chem. 2017 Apr 27;60(8):3405-3421. doi: 10.1021/acs.jmedchem.7b00162. Epub 2017 Apr 17. J Med Chem. 2017. PMID: 28368581

5

Effects of selective and non-selective glucocorticoid receptor II antagonists on rapid-onset diabetes in young rats.

Beaudry JL, Dunford EC, Teich T, Zaharieva D, Hunt H, Belanoff JK, Riddell MC. Beaudry JL, et al. Among authors: hunt h. PLoS One. 2014 Mar 18;9(3):e91248. doi: 10.1371/journal.pone.0091248. eCollection 2014. PLoS One. 2014. PMID: 24642683 Free PMC article.

6

FKBP5 mRNA Expression Is a Biomarker for GR Antagonism.

Bali U, Phillips T, Hunt H, Unitt J. Bali U, et al. Among authors: hunt h. J Clin Endocrinol Metab. 2016 Nov;101(11):4305-4312. doi: 10.1210/jc.2016-1624. Epub 2016 Jul 26. J Clin Endocrinol Metab. 2016. PMID: 27459525 Clinical Trial.

7

The development of novel glucocorticoid receptor antagonists: From rational chemical design to therapeutic efficacy in metabolic disease models.

Kroon J, Viho EMG, Gentenaar M, Koorneef LL, van Kooten C, Rensen PCN, Kooijman S, Hunt H, Meijer OC. Kroon J, et al. Among authors: hunt h. Pharmacol Res. 2021 Jun;168:105588. doi: 10.1016/j.phrs.2021.105588. Epub 2021 Mar 31. Pharmacol Res. 2021. PMID: 33798733 Free article.

8

Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat.

Hunt HJ, Ray NC, Hynd G, Sutton J, Sajad M, O'Connor E, Ahmed S, Lockey P, Daly S, Buckley G, Clark RD, Roe R, Blasey C, Belanoff J. Hunt HJ, et al. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7376-80. doi: 10.1016/j.bmcl.2012.10.074. Epub 2012 Oct 23. Bioorg Med Chem Lett. 2012. PMID: 23131342

9

Selective Glucocorticoid Receptor Antagonist CORT125281 Activates Brown Adipose Tissue and Alters Lipid Distribution in Male Mice.

Kroon J, Koorneef LL, van den Heuvel JK, Verzijl CRC, van de Velde NM, Mol IM, Sips HCM, Hunt H, Rensen PCN, Meijer OC. Kroon J, et al. Among authors: hunt h. Endocrinology. 2018 Jan 1;159(1):535-546. doi: 10.1210/en.2017-00512. Endocrinology. 2018. PMID: 28938459

10

Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases.

De Nicola AF, Meyer M, Guennoun R, Schumacher M, Hunt H, Belanoff J, de Kloet ER, Gonzalez Deniselle MC. De Nicola AF, et al. Among authors: hunt h. Int J Mol Sci. 2020 Mar 20;21(6):2137. doi: 10.3390/ijms21062137. Int J Mol Sci. 2020. PMID: 32244957 Free PMC article. Review.

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