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Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid.
Mélin L, Abdullayev S, Fnaiche A, Vu V, González Suárez N, Zeng H, Szewczyk MM, Li F, Senisterra G, Allali-Hassani A, Chau I, Dong A, Woo S, Annabi B, Halabelian L, LaPlante SR, Vedadi M, Barsyte-Lovejoy D, Santhakumar V, Gagnon A. Mélin L, et al. Among authors: gagnon a. ChemMedChem. 2021 Oct 6;16(19):2982-3002. doi: 10.1002/cmdc.202100432. Epub 2021 Jul 28. ChemMedChem. 2021. PMID: 34164919
Synthesis of NVS-BPTF-1 and evaluation of its biological activity.
Mélin L, Calosing C, Kharenko OA, Hansen HC, Gagnon A. Mélin L, et al. Among authors: gagnon a. Bioorg Med Chem Lett. 2021 Sep 1;47:128208. doi: 10.1016/j.bmcl.2021.128208. Epub 2021 Jun 16. Bioorg Med Chem Lett. 2021. PMID: 34146702
On the Barton Copper-Catalyzed C3-Arylation of Indoles using Triarylbismuth bis(trifluoroacetate) Reagents.
Fnaiche A, Bueno B, McMullin CL, Gagnon A. Fnaiche A, et al. Among authors: gagnon a. Chempluschem. 2023 May 17:e202300218. doi: 10.1002/cplu.202300218. Online ahead of print. Chempluschem. 2023. PMID: 37194987
Invited for this month's cover are the collaborating groups of Prof. Alexandre Gagnon at the Universite du Quebec a Montreal in Canada, and Dr. Claire McMullin at the University of Bath in the UK. ...The aryl groups are being transferred from a pentavalent tr …
Invited for this month's cover are the collaborating groups of Prof. Alexandre Gagnon at the Universite du Quebec a Montreal i …
Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay.
Stammers TA, Coulombe R, Duplessis M, Fazal G, Gagnon A, Garneau M, Goulet S, Jakalian A, LaPlante S, Rancourt J, Thavonekham B, Wernic D, Kukolj G, Beaulieu PL. Stammers TA, et al. Among authors: gagnon a. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6879-85. doi: 10.1016/j.bmcl.2013.09.102. Epub 2013 Oct 8. Bioorg Med Chem Lett. 2013. PMID: 24176401
Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity.
Beaulieu PL, Bolger G, Deon D, Duplessis M, Fazal G, Gagnon A, Garneau M, LaPlante S, Stammers T, Kukolj G, Duan J. Beaulieu PL, et al. Among authors: gagnon a. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1140-5. doi: 10.1016/j.bmcl.2014.12.078. Epub 2015 Jan 3. Bioorg Med Chem Lett. 2015. PMID: 25599836
Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth.
Garapaty-Rao S, Nasveschuk C, Gagnon A, Chan EY, Sandy P, Busby J, Balasubramanian S, Campbell R, Zhao F, Bergeron L, Audia JE, Albrecht BK, Harmange JC, Cummings R, Trojer P. Garapaty-Rao S, et al. Among authors: gagnon a. Chem Biol. 2013 Nov 21;20(11):1329-39. doi: 10.1016/j.chembiol.2013.09.013. Epub 2013 Oct 31. Chem Biol. 2013. PMID: 24183969
522 results