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Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid.
ChemMedChem. 2021 Oct 6;16(19):2982-3002. doi: 10.1002/cmdc.202100432. Epub 2021 Jul 28.
ChemMedChem. 2021.
PMID: 34164919
Synthesis of aryl cyclopropyl sulfides through copper-promoted S-cyclopropylation of thiophenols using cyclopropylboronic acid.
Benoit E, Fnaiche A, Gagnon A.
Benoit E, et al. Among authors: fnaiche a.
Beilstein J Org Chem. 2019 May 27;15:1162-1171. doi: 10.3762/bjoc.15.113. eCollection 2019.
Beilstein J Org Chem. 2019.
PMID: 31293663
Free PMC article.
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On the Barton Copper-Catalyzed C3-Arylation of Indoles using Triarylbismuth bis(trifluoroacetate) Reagents.
Fnaiche A, Bueno B, McMullin CL, Gagnon A.
Fnaiche A, et al.
Chempluschem. 2023 Aug;88(8):e202200465. doi: 10.1002/cplu.202200465. Epub 2023 Mar 15.
Chempluschem. 2023.
PMID: 36843381
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On the Barton Copper-Catalyzed C3-Arylation of Indoles using Triarylbismuth bis(trifluoroacetate) Reagents.
Fnaiche A, Bueno B, McMullin CL, Gagnon A.
Fnaiche A, et al.
Chempluschem. 2023 May 17:e202300218. doi: 10.1002/cplu.202300218. Online ahead of print.
Chempluschem. 2023.
PMID: 37194987
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Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration.
Fnaiche A, Chan HC, Paquin A, González Suárez N, Vu V, Li F, Allali-Hassani A, Cao MA, Szewczyk MM, Bolotokova A, Allemand F, Gelin M, Barsyte-Lovejoy D, Santhakumar V, Vedadi M, Guichou JF, Annabi B, Gagnon A.
Fnaiche A, et al.
ACS Med Chem Lett. 2023 Nov 30;14(12):1746-1753. doi: 10.1021/acsmedchemlett.3c00386. eCollection 2023 Dec 14.
ACS Med Chem Lett. 2023.
PMID: 38116405
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Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings.
Fnaiche A, Mélin L, Suárez NG, Paquin A, Vu V, Li F, Allali-Hassani A, Bolotokova A, Allemand F, Gelin M, Cotelle P, Woo S, LaPlante SR, Barsyte-Lovejoy D, Santhakumar V, Vedadi M, Guichou JF, Annabi B, Gagnon A.
Fnaiche A, et al.
Bioorg Med Chem Lett. 2023 Oct 15;95:129488. doi: 10.1016/j.bmcl.2023.129488. Epub 2023 Sep 27.
Bioorg Med Chem Lett. 2023.
PMID: 37770003
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