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Solving the Problem of Assessing Synergy and Antagonism for Non-Traditional Dosing Curve Compounds Using the DE/ZI Method: Application to Nrf2 Activators.
Front Pharmacol. 2021 Jun 7;12:686201. doi: 10.3389/fphar.2021.686201. eCollection 2021.
Front Pharmacol. 2021.
PMID: 34163365
Free PMC article.
Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology.
Upadhyaya P, Kristensson J, Lahdenranta J, Repash E, Ma J, Kublin J, Mudd GE, Luus L, Jeffrey P, Hurov K, McDonnell K, Keen N.
Upadhyaya P, et al.
J Med Chem. 2022 Jul 28;65(14):9858-9872. doi: 10.1021/acs.jmedchem.2c00505. Epub 2022 Jul 12.
J Med Chem. 2022.
PMID: 35819182
Free PMC article.
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Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist.
Upadhyaya P, Lahdenranta J, Hurov K, Battula S, Dods R, Haines E, Kleyman M, Kristensson J, Kublin J, Lani R, Ma J, Mudd G, Repash E, Van Rietschoten K, Stephen T, You F, Harrison H, Chen L, McDonnell K, Brandish P, Keen N.
Upadhyaya P, et al.
J Immunother Cancer. 2021 Jan;9(1):e001762. doi: 10.1136/jitc-2020-001762.
J Immunother Cancer. 2021.
PMID: 33500260
Free PMC article.
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BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™) induces tumor localized CD137 agonism.
Hurov K, Lahdenranta J, Upadhyaya P, Haines E, Cohen H, Repash E, Kanakia D, Ma J, Kristensson J, You F, Campbell C, Witty D, Kelly M, Blakemore S, Jeffrey P, McDonnell K, Brandish P, Keen N.
Hurov K, et al.
J Immunother Cancer. 2021 Nov;9(11):e002883. doi: 10.1136/jitc-2021-002883.
J Immunother Cancer. 2021.
PMID: 34725211
Free PMC article.
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