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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.
Cortellino S, Xu J, Sannai M, Moore R, Caretti E, Cigliano A, Le Coz M, Devarajan K, Wessels A, Soprano D, Abramowitz LK, Bartolomei MS, Rambow F, Bassi MR, Bruno T, Fanciulli M, Renner C, Klein-Szanto AJ, Matsumoto Y, Kobi D, Davidson I, Alberti C, Larue L, Bellacosa A. Cortellino S, et al. Among authors: bellacosa a. Cell. 2011 Jul 8;146(1):67-79. doi: 10.1016/j.cell.2011.06.020. Epub 2011 Jun 30. Cell. 2011. PMID: 21722948 Free PMC article.
DNA demethylation by TDG.
Dalton SR, Bellacosa A. Dalton SR, et al. Among authors: bellacosa a. Epigenomics. 2012 Aug;4(4):459-67. doi: 10.2217/epi.12.36. Epigenomics. 2012. PMID: 22920184 Free PMC article. Review.
The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity.
Cortellino S, Turner D, Masciullo V, Schepis F, Albino D, Daniel R, Skalka AM, Meropol NJ, Alberti C, Larue L, Bellacosa A. Cortellino S, et al. Among authors: bellacosa a. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15071-6. doi: 10.1073/pnas.2334585100. Epub 2003 Nov 12. Proc Natl Acad Sci U S A. 2003. PMID: 14614141 Free PMC article.
Thymine DNA glycosylase as a novel target for melanoma.
Mancuso P, Tricarico R, Bhattacharjee V, Cosentino L, Kadariya Y, Jelinek J, Nicolas E, Einarson M, Beeharry N, Devarajan K, Katz RA, Dorjsuren DG, Sun H, Simeonov A, Giordano A, Testa JR, Davidson G, Davidson I, Larue L, Sobol RW, Yen TJ, Bellacosa A. Mancuso P, et al. Among authors: bellacosa a. Oncogene. 2019 May;38(19):3710-3728. doi: 10.1038/s41388-018-0640-2. Epub 2019 Jan 23. Oncogene. 2019. PMID: 30674989 Free PMC article.
Induction of deoxyribonucleic acid damage by alkylating agents.
Cortellino S, Turner DP, Albino D, Bellacosa A. Cortellino S, et al. Among authors: bellacosa a. Methods Mol Biol. 2004;285:121-5. doi: 10.1385/1-59259-822-6:121. Methods Mol Biol. 2004. PMID: 15269405 Review. No abstract available.
134 results