Zhang L - Search Results

1

Strategies for Targeting Serine/Threonine Protein Phosphatases with Small Molecules in Cancer.

Zhang Q, Fan Z, Zhang L, You Q, Wang L. Zhang Q, et al. Among authors: zhang l. J Med Chem. 2021 Jul 8;64(13):8916-8938. doi: 10.1021/acs.jmedchem.1c00631. Epub 2021 Jun 22. J Med Chem. 2021. PMID: 34156850 Review.

2

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Xu LL, Zhu JF, Xu XL, Zhu J, Li L, Xi MY, Jiang ZY, Zhang MY, Liu F, Lu MC, Bao QC, Li Q, Zhang C, Wei JL, Zhang XJ, Zhang LS, You QD, Sun HP. Xu LL, et al. Among authors: zhang ls, zhang c, zhang my, zhang xj. J Med Chem. 2015 Jul 23;58(14):5419-36. doi: 10.1021/acs.jmedchem.5b00170. Epub 2015 Jul 7. J Med Chem. 2015. PMID: 26111355

3

Palladium(II)-Catalyzed C-H Bond Activation/C-C Coupling/Intramolecular Tsuji-Trost Reaction Cascade: Facile Access to 2H-Pyranonaphthoquinones.

Bian J, Qian X, Wang N, Mu T, Li X, Sun H, Zhang L, You Q, Zhang X. Bian J, et al. Among authors: zhang l, zhang x. Org Lett. 2015 Jul 17;17(14):3410-3. doi: 10.1021/acs.orglett.5b01304. Epub 2015 Jul 7. Org Lett. 2015. PMID: 26151353

4

Affinity-Based Fluorescence Polarization Assay for High-Throughput Screening of Prolyl Hydroxylase 2 Inhibitors.

Lei Y, Hu T, Wu X, Wu Y, Bao Q, Zhang L, Xia H, Sun H, You Q, Zhang X. Lei Y, et al. Among authors: zhang l, zhang x. ACS Med Chem Lett. 2015 Nov 9;6(12):1236-40. doi: 10.1021/acsmedchemlett.5b00394. eCollection 2015 Dec 10. ACS Med Chem Lett. 2015. PMID: 26713111 Free PMC article.

5

Discovery of EBI-1051: A novel and orally efficacious MEK inhibitor with benzofuran scaffold.

Lu B, Huang S, Cao J, Hu Q, Shen R, Wan H, Wang D, Yuan J, Zhang L, Zhang J, Zhang M, Tao W, Zhang L. Lu B, et al. Among authors: zhang l, zhang m, zhang j. Bioorg Med Chem. 2018 Feb 1;26(3):581-589. doi: 10.1016/j.bmc.2017.12.019. Epub 2017 Dec 20. Bioorg Med Chem. 2018. PMID: 29317148

6

SHR-A1403, a novel c-Met antibody-drug conjugate, exerts encouraging anti-tumor activity in c-Met-overexpressing models.

Yang CY, Wang L, Sun X, Tang M, Quan HT, Zhang LS, Lou LG, Gou SH. Yang CY, et al. Among authors: zhang ls. Acta Pharmacol Sin. 2019 Jul;40(7):971-979. doi: 10.1038/s41401-018-0198-0. Epub 2019 Jan 14. Acta Pharmacol Sin. 2019. PMID: 30643210 Free PMC article.

7

Discovery of Clinical Candidate (5-(3-(4-Chlorophenoxy)prop-1-yn-1-yl)-3-hydroxypicolinoyl)glycine, an Orally Bioavailable Prolyl Hydroxylase Inhibitor for the Treatment of Anemia.

Zhang X, Lei Y, Hu T, Wu Y, Li Z, Jiang Z, Yang C, Zhang L, You Q. Zhang X, et al. Among authors: zhang l. J Med Chem. 2020 Sep 10;63(17):10045-10060. doi: 10.1021/acs.jmedchem.0c01161. Epub 2020 Aug 5. J Med Chem. 2020. PMID: 32787144

8

Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core.

Zhang Q, Wu X, Zhou J, Zhang L, Xu X, Zhang L, You Q, Wang L. Zhang Q, et al. Among authors: zhang l. Eur J Med Chem. 2021 Jan 15;210:112959. doi: 10.1016/j.ejmech.2020.112959. Epub 2020 Oct 22. Eur J Med Chem. 2021. PMID: 33109397

9

Protein Phosphatase 5-Recruiting Chimeras for Accelerating Apoptosis-Signal-Regulated Kinase 1 Dephosphorylation with Antiproliferative Activity.

Zhang Q, Wu X, Zhang H, Wu Q, Fu M, Hua L, Zhu X, Guo Y, Zhang L, You Q, Wang L. Zhang Q, et al. Among authors: zhang l, zhang h. J Am Chem Soc. 2023 Jan 18;145(2):1118-1128. doi: 10.1021/jacs.2c10759. Epub 2022 Dec 22. J Am Chem Soc. 2023. PMID: 36546850

10

BJTJ-1837, a novel FXI activation-blocking antibody.

He X, Zhang J, Du Y, Liu X, Hu D, Cao B, Gao H, Wu Y, Zhou T, Wu Q, Huang Q, Yang C, Liao C, Zhang L, Shen C, Wang L. He X, et al. Among authors: zhang l, zhang j. Res Pract Thromb Haemost. 2023 Feb 7;7(2):100067. doi: 10.1016/j.rpth.2023.100067. eCollection 2023 Feb. Res Pract Thromb Haemost. 2023. PMID: 36936858 Free PMC article.

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