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Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype.
Polubothu S, Zecchin D, Al-Olabi L, Lionarons DA, Harland M, Horswell S, Thomas AC, Hunt L, Wlodarchak N, Aguilera P, Brand S, Bryant D, Carrera C, Chen H, Elgar G, Harwood CA, Howell M, Larue L, Loughlin S, MacDonald J, Malvehy J, Barberan SM, da Silva VM, Molina M, Morrogh D, Moulding D, Nsengimana J, Pittman A, Puig-Butillé JA, Parmar K, Sebire NJ, Scherer S, Stadnik P, Stanier P, Tell G, Waelchli R, Zarrei M, Puig S, Bataille V, Xing Y, Healy E, Moore GE, Di WL, Newton-Bishop J, Downward J, Kinsler VA. Polubothu S, et al. Among authors: chen h. Genet Med. 2021 Sep;23(9):1636-1647. doi: 10.1038/s41436-021-01204-y. Epub 2021 Jun 18. Genet Med. 2021. PMID: 34145395 Free PMC article.
Methylation-regulated decommissioning of multimeric PP2A complexes.
Wu CG, Zheng A, Jiang L, Rowse M, Stanevich V, Chen H, Li Y, Satyshur KA, Johnson B, Gu TJ, Liu Z, Xing Y. Wu CG, et al. Among authors: chen h. Nat Commun. 2017 Dec 22;8(1):2272. doi: 10.1038/s41467-017-02405-3. Nat Commun. 2017. PMID: 29273778 Free PMC article.
PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis.
Wu CG, Chen H, Guo F, Yadav VK, Mcilwain SJ, Rowse M, Choudhary A, Lin Z, Li Y, Gu T, Zheng A, Xu Q, Lee W, Resch E, Johnson B, Day J, Ge Y, Ong IM, Burkard ME, Ivarsson Y, Xing Y. Wu CG, et al. Among authors: chen h. Cell Discov. 2017 Aug 8;3:17027. doi: 10.1038/celldisc.2017.27. eCollection 2017. Cell Discov. 2017. PMID: 28884018 Free PMC article.
Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR).
Seok SH, Ma ZX, Feltenberger JB, Chen H, Chen H, Scarlett C, Lin Z, Satyshur KA, Cortopassi M, Jefcoate CR, Ge Y, Tang W, Bradfield CA, Xing Y. Seok SH, et al. Among authors: chen h. J Biol Chem. 2018 Feb 9;293(6):1994-2005. doi: 10.1074/jbc.RA117.000631. Epub 2017 Dec 26. J Biol Chem. 2018. PMID: 29279331 Free PMC article.
Nobiletin derivative, 5-acetoxy-6,7,8,3',4'-pentamethoxyflavone, inhibits neuroinflammation through the inhibition of TLR4/MyD88/MAPK signaling pathways and STAT3 in microglia.
Chuang JM, Chen HL, Chang CI, Lin JS, Chang HM, Wu WJ, Lin MY, Chen WF, Lee CH. Chuang JM, et al. Among authors: chen hl. Immunopharmacol Immunotoxicol. 2024 May 27:1-15. doi: 10.1080/08923973.2024.2360050. Online ahead of print. Immunopharmacol Immunotoxicol. 2024. PMID: 38800857
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