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Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size.
He W, McCarroll CS, Nather K, Ford K, Mangion K, Riddell A, O'Toole D, Zaeri A, Corcoran D, Carrick D, Lee MMY, McEntegart M, Davie A, Good R, Lindsay MM, Eteiba H, Rocchiccioli P, Watkins S, Hood S, Shaukat A, McArthur L, Elliott EB, McClure J, Hawksby C, Martin T, Petrie MC, Oldroyd KG, Smith GL; Oxford Acute Myocardial Infarction (OxAMI) Study; Channon KM, Berry C, Nicklin SA, Loughrey CM. He W, et al. Among authors: martin t. Cardiovasc Res. 2022 May 6;118(6):1535-1547. doi: 10.1093/cvr/cvab204. Cardiovasc Res. 2022. PMID: 34132807 Free PMC article.
RUNX1: an emerging therapeutic target for cardiovascular disease.
Riddell A, McBride M, Braun T, Nicklin SA, Cameron E, Loughrey CM, Martin TP. Riddell A, et al. Among authors: martin tp. Cardiovasc Res. 2020 Jul 1;116(8):1410-1423. doi: 10.1093/cvr/cvaa034. Cardiovasc Res. 2020. PMID: 32154891 Free PMC article. Review.
Ribonucleicacid interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction.
Martin TP, MacDonald EA, Bradley A, Watson H, Saxena P, Rog-Zielinska EA, Raheem A, Fisher S, Elbassioni AAM, Almuzaini O, Booth C, Campbell M, Riddell A, Herzyk P, Blyth K, Nixon C, Zentilin L, Berry C, Braun T, Giacca M, McBride MW, Nicklin SA, Cameron ER, Loughrey CM. Martin TP, et al. Cardiovasc Res. 2023 Dec 19;119(16):2663-2671. doi: 10.1093/cvr/cvad107. Cardiovasc Res. 2023. PMID: 37433039 Free PMC article.
A novel ryanodine receptor 2 inhibitor, M201-A, enhances natriuresis, renal function and lusi-inotropic actions: Preclinical and phase I study.
Kaneko N, Loughrey CM, Smith G, Matsuda R, Hasunuma T, Mark PB, Toda M, Shinozaki M, Otani N, Kayley S, Da Silva Costa A, Martin TP, Dobi S, Saxena P, Shimamoto K, Ishikawa T, Kambayashi R, Riddell A, Elliott EB, McCarroll CS, Sakai T, Mitsuhisa Y, Hirano S, Kitai T, Kusano K, Inoue Y, Nakamura M, Kikuchi M, Toyoda S, Taguchi I, Fujiwara T, Sugiyama A, Kumagai Y, Iwata K. Kaneko N, et al. Among authors: martin tp. Br J Pharmacol. 2024 May 21. doi: 10.1111/bph.16379. Online ahead of print. Br J Pharmacol. 2024. PMID: 38773354
4,773 results