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Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons.
Sanchez CG, Acker CM, Gray A, Varadarajan M, Song C, Cochran NR, Paula S, Lindeman A, An S, McAllister G, Alford J, Reece-Hoyes J, Russ C, Craig L, Capre K, Doherty C, Hoffman GR, Luchansky SJ, Polydoro M, Dolmetsch R, Elwood F. Sanchez CG, et al. Among authors: dolmetsch r. Commun Biol. 2021 Jun 14;4(1):736. doi: 10.1038/s42003-021-02272-1. Commun Biol. 2021. PMID: 34127790 Free PMC article.
Genome-Scale CRISPR Screens Identify Human Pluripotency-Specific Genes.
Ihry RJ, Salick MR, Ho DJ, Sondey M, Kommineni S, Paula S, Raymond J, Henry B, Frias E, Wang Q, Worringer KA, Ye C, Russ C, Reece-Hoyes JS, Altshuler RC, Randhawa R, Yang Z, McAllister G, Hoffman GR, Dolmetsch R, Kaykas A. Ihry RJ, et al. Among authors: dolmetsch r. Cell Rep. 2019 Apr 9;27(2):616-630.e6. doi: 10.1016/j.celrep.2019.03.043. Cell Rep. 2019. PMID: 30970262 Free article.
p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells.
Ihry RJ, Worringer KA, Salick MR, Frias E, Ho D, Theriault K, Kommineni S, Chen J, Sondey M, Ye C, Randhawa R, Kulkarni T, Yang Z, McAllister G, Russ C, Reece-Hoyes J, Forrester W, Hoffman GR, Dolmetsch R, Kaykas A. Ihry RJ, et al. Among authors: dolmetsch r. Nat Med. 2018 Jul;24(7):939-946. doi: 10.1038/s41591-018-0050-6. Epub 2018 Jun 11. Nat Med. 2018. PMID: 29892062
The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia.
Nehme R, Pietiläinen O, Artomov M, Tegtmeyer M, Valakh V, Lehtonen L, Bell C, Singh T, Trehan A, Sherwood J, Manning D, Peirent E, Malik R, Guss EJ, Hawes D, Beccard A, Bara AM, Hazelbaker DZ, Zuccaro E, Genovese G, Loboda AA, Neumann A, Lilliehook C, Kuismin O, Hamalainen E, Kurki M, Hultman CM, Kähler AK, Paulo JA, Ganna A, Madison J, Cohen B, McPhie D, Adolfsson R, Perlis R, Dolmetsch R, Farhi S, McCarroll S, Hyman S, Neale B, Barrett LE, Harper W, Palotie A, Daly M, Eggan K. Nehme R, et al. Among authors: dolmetsch r. Nat Commun. 2022 Jun 27;13(1):3690. doi: 10.1038/s41467-022-31436-8. Nat Commun. 2022. PMID: 35760976 Free PMC article.
An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion.
Keller CG, Shin Y, Monteys AM, Renaud N, Beibel M, Teider N, Peters T, Faller T, St-Cyr S, Knehr J, Roma G, Reyes A, Hild M, Lukashev D, Theil D, Dales N, Cha JH, Borowsky B, Dolmetsch R, Davidson BL, Sivasankaran R. Keller CG, et al. Among authors: dolmetsch r. Nat Commun. 2022 Mar 3;13(1):1150. doi: 10.1038/s41467-022-28653-6. Nat Commun. 2022. PMID: 35241644 Free PMC article.
Translating genome-wide association findings into new therapeutics for psychiatry.
Breen G, Li Q, Roth BL, O'Donnell P, Didriksen M, Dolmetsch R, O'Reilly PF, Gaspar HA, Manji H, Huebel C, Kelsoe JR, Malhotra D, Bertolino A, Posthuma D, Sklar P, Kapur S, Sullivan PF, Collier DA, Edenberg HJ. Breen G, et al. Among authors: dolmetsch r. Nat Neurosci. 2016 Oct 26;19(11):1392-1396. doi: 10.1038/nn.4411. Nat Neurosci. 2016. PMID: 27786187 Free PMC article. Review.
CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency.
Bidinosti M, Botta P, Krüttner S, Proenca CC, Stoehr N, Bernhard M, Fruh I, Mueller M, Bonenfant D, Voshol H, Carbone W, Neal SJ, McTighe SM, Roma G, Dolmetsch RE, Porter JA, Caroni P, Bouwmeester T, Lüthi A, Galimberti I. Bidinosti M, et al. Science. 2016 Mar 11;351(6278):1199-203. doi: 10.1126/science.aad5487. Epub 2016 Feb 4. Science. 2016. PMID: 26847545
82 results