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Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.
Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Zhang Y, Aleman-Muench GR, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton SA, Soroosh P, Teijaro J, de la Torre JC, Arditi M, Karin M, Sanchez-Lopez E. Xian H, et al. Among authors: chen w. Immunity. 2021 Jul 13;54(7):1463-1477.e11. doi: 10.1016/j.immuni.2021.05.004. Epub 2021 Jun 10. Immunity. 2021. PMID: 34115964 Free PMC article.
Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis.
Chen PB, Black AS, Sobel AL, Zhao Y, Mukherjee P, Molparia B, Moore NE, Aleman Muench GR, Wu J, Chen W, Pinto AFM, Maryanoff BE, Saghatelian A, Soroosh P, Torkamani A, Leman LJ, Ghadiri MR. Chen PB, et al. Among authors: chen w. Nat Biotechnol. 2020 Nov;38(11):1288-1297. doi: 10.1038/s41587-020-0549-5. Epub 2020 Jun 15. Nat Biotechnol. 2020. PMID: 32541956 Free PMC article.
Identification and characterization of select oxysterols as ligands for GPR17.
Harrington AW, Liu C, Phillips N, Nepomuceno D, Kuei C, Chang J, Chen W, Sutton SW, O'Malley D, Pham L, Yao X, Sun S, Bonaventure P. Harrington AW, et al. Among authors: chen w. Br J Pharmacol. 2023 Feb;180(4):401-421. doi: 10.1111/bph.15969. Epub 2022 Nov 14. Br J Pharmacol. 2023. PMID: 36214386 Free article.
Nobiletin derivative, 5-acetoxy-6,7,8,3',4'-pentamethoxyflavone, inhibits neuroinflammation through the inhibition of TLR4/MyD88/MAPK signaling pathways and STAT3 in microglia.
Chuang JM, Chen HL, Chang CI, Lin JS, Chang HM, Wu WJ, Lin MY, Chen WF, Lee CH. Chuang JM, et al. Among authors: chen wf. Immunopharmacol Immunotoxicol. 2024 May 27:1-15. doi: 10.1080/08923973.2024.2360050. Online ahead of print. Immunopharmacol Immunotoxicol. 2024. PMID: 38800857
Scalp Metastasis After Breast Cancer Surgery: A Case Report.
Wu J, Zhang W, Zhang H, Lu X, Luan B, Yang Q, Chen L, Chen W, Ge F. Wu J, et al. Among authors: chen w. Onco Targets Ther. 2024 May 23;17:411-419. doi: 10.2147/OTT.S456532. eCollection 2024. Onco Targets Ther. 2024. PMID: 38800451 Free PMC article.
Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery.
Qian C, Zhou Y, Zhang T, Dong G, Song M, Tang Y, Wei Z, Yu S, Shen Q, Chen W, Choi JP, Yan J, Zhong C, Wan L, Li J, Wang A, Lu Y, Zhao Y. Qian C, et al. Among authors: chen w. Acta Pharm Sin B. 2024 May;14(5):2077-2096. doi: 10.1016/j.apsb.2024.02.003. Epub 2024 Feb 23. Acta Pharm Sin B. 2024. PMID: 38799619 Free PMC article.
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