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Risk stratification of cervical lesions using capture sequencing and machine learning method based on HPV and human integrated genomic profiles.
Tian R, Cui Z, He D, Tian X, Gao Q, Ma X, Yang JR, Wu J, Das BC, Severinov K, Hitzeroth II, Debata PR, Xu W, Zhong H, Fan W, Chen Y, Jin Z, Cao C, Yu M, Xie W, Huang Z, Bao Y, Xie H, Yao S, Hu Z. Tian R, et al. Among authors: huang z. Carcinogenesis. 2019 Oct 16;40(10):1220-1228. doi: 10.1093/carcin/bgz094. Carcinogenesis. 2019. PMID: 31102403
Hyperbranched poly(β-amino ester) based polyplex nanopaticles for delivery of CRISPR/Cas9 system and treatment of HPV infection associated cervical cancer.
Gao X, Jin Z, Tan X, Zhang C, Zou C, Zhang W, Ding J, Das BC, Severinov K, Hitzeroth II, Debata PR, He D, Ma X, Tian X, Gao Q, Wu J, Tian R, Cui Z, Fan W, Huang Z, Cao C, Bao Y, Tan S, Hu Z. Gao X, et al. Among authors: huang z. J Control Release. 2020 May 10;321:654-668. doi: 10.1016/j.jconrel.2020.02.045. Epub 2020 Feb 28. J Control Release. 2020. PMID: 32114092
In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs' cleavage by CRISPR/Cas13a system.
Chen Y, Jiang H, Wang T, He D, Tian R, Cui Z, Tian X, Gao Q, Ma X, Yang J, Wu J, Tan S, Xu H, Tang X, Wang Y, Yu Z, Han H, Das BC, Severinov K, Hitzeroth II, Debata PR, Xu W, Fan W, Jin Z, Cao C, Yu M, Xie W, Huang Z, Hu Z, You Z. Chen Y, et al. Among authors: huang z. Antiviral Res. 2020 Jun;178:104794. doi: 10.1016/j.antiviral.2020.104794. Epub 2020 Apr 14. Antiviral Res. 2020. PMID: 32298665
An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (β-amino ester) nanoparticles for vaginal gene therapy.
Niu G, Jin Z, Zhang C, He D, Gao X, Zou C, Zhang W, Ding J, Das BC, Severinov K, Hitzeroth II, Debata PR, Ma X, Tian X, Gao Q, Wu J, You Z, Tian R, Cui Z, Fan W, Xie W, Huang Z, Cao C, Xu W, Xie H, Xu H, Tang X, Wang Y, Yu Z, Han H, Tan S, Chen S, Hu Z. Niu G, et al. Among authors: huang z. EBioMedicine. 2020 Aug;58:102897. doi: 10.1016/j.ebiom.2020.102897. Epub 2020 Jul 22. EBioMedicine. 2020. PMID: 32711250 Free PMC article.
DeepHPV: a deep learning model to predict human papillomavirus integration sites.
Tian R, Zhou P, Li M, Tan J, Cui Z, Xu W, Wei J, Zhu J, Jin Z, Cao C, Fan W, Xie W, Huang Z, Xie H, You Z, Niu G, Wu C, Guo X, Weng X, Tian X, Yu F, Yu Z, Liang J, Hu Z. Tian R, et al. Among authors: huang z. Brief Bioinform. 2021 Jul 20;22(4):bbaa242. doi: 10.1093/bib/bbaa242. Brief Bioinform. 2021. PMID: 33059369
The comparison of ZFNs, TALENs, and SpCas9 by GUIDE-seq in HPV-targeted gene therapy.
Cui Z, Liu H, Zhang H, Huang Z, Tian R, Li L, Fan W, Chen Y, Chen L, Zhang S, Das BC, Severinov K, Hitzeroth II, Debata PR, Jin Z, Liu J, Huang Z, Xie W, Xie H, Lang B, Ma J, Weng H, Tian X, Hu Z. Cui Z, et al. Among authors: huang z. Mol Ther Nucleic Acids. 2021 Aug 19;26:1466-1478. doi: 10.1016/j.omtn.2021.08.008. eCollection 2021 Dec 3. Mol Ther Nucleic Acids. 2021. PMID: 34938601 Free PMC article.
FrCas9 is a CRISPR/Cas9 system with high editing efficiency and fidelity.
Cui Z, Tian R, Huang Z, Jin Z, Li L, Liu J, Huang Z, Xie H, Liu D, Mo H, Zhou R, Lang B, Meng B, Weng H, Hu Z. Cui Z, et al. Among authors: huang z. Nat Commun. 2022 Mar 17;13(1):1425. doi: 10.1038/s41467-022-29089-8. Nat Commun. 2022. PMID: 35301321 Free PMC article.
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